Hyaluronic acid‐g‐lipoic acid granular gel for promoting diabetic wound healing

Abstract

Diabetic patients are prone to developing chronic inflammation after trauma and have persistent nonhealing wounds. Reactive oxygen species (ROS) and recurrent bacterial infections at the site of long-term wounds also further delay skin wound healing and tissue regeneration. In this study, a granular gel (which exhibits ROS scavenging and antibacterial properties) is fabricated based on hyaluronic acid-g-lipoic acid (HA-LA). Briefly, HA-LA is synthesized to fabricate HA-LA microgels, which are further assembled by Ag + via its coordination effect with disulfide in dithiolane to form a granular gel. The extrudable bulk granular gel possesses a shear-thinning fea-

Tissue adhesive indocyanine green‐locking granular gel‐mediated photothermal therapy combined with checkpoint inhibitor for preventing postsurgical recurrence and metastasis of colorectal cancer

“…Strain scanning measurements were carried out at a constant frequency of 1 Hz and a strain range from 0.1% to 1000%. The shear‐thinning behavior was studied by measuring the viscosity change with the shear rate increased from 0.001 to 100 s −1 continuously 25 …”

“…The shear-thinning behavior was studied by measuring the viscosity change with the shear rate increased from 0.001 to 100 s À1 continuously. 25 For the swelling test, the vacuum-dried granular hydrogels were weighted and immersed in deionized water at 25 C and weighed at 5, 10, 30, 60, 180, 300, 600, and 1800 s. The swelling ratio was calculated according to the following formula: SR = (W x -W 0 )/W 0 , where W x was the wet weight of the hydrogels at different time points, and W 0 was the dry weight of the hydrogels. 25…”

Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds

“…Moreover, the antimicrobial activity test showed that the HA-LA granular gel inhibited the growth of S. aureus due to the presence of Ag+. Finally, in vivo experiments demonstrate that the HA-LA granular gel effectively reduces excessive ROS at the wound site, enhances the secretion of reparative growth factors, and significantly accelerates both common and diabetic wound healing [ 195 ].…”

Construction of injectable collagen-microgel/tannic acid/nano-hydroxyapatite granular hydrogel and evaluation of its potential in wound healing

“…can be used for the design of interaction between micro-particles due to their bonding and breaking ability under mild conditions. 15–18…”

“…can be used for the design of interaction between micro-particles due to their bonding and breaking ability under mild conditions. [15][16][17][18] Collagen (COL), the main component of musculoskeletal tissue and forms the ECM of most tissues, is one of the most attractive polymers, which has been widely used in tissue engineering. 19 COL-based hydrogels are favorable for tissue engineering purposes, because COL is highly biocompatible and abundant, which makes it the material of choice for many wound healing studies.…”