Hyaluronic acid in hydrophilic contact lenses: Spectroscopic investigation of the content and release in solution

Fagnola, Matteo; Pagani, Marco; Maffioletti, Silvio; Tavazzi, Silvia; Papagni, Antonio

doi:10.1016/j.clae.2009.02.006

Cited by 46 publications

(34 citation statements)

References 23 publications

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“…The ability of contact lenses to attract, retain and release polyanions has already been described in literature for hyaluronic acid (Scheuer et al, 2010;Fagnola et al, 2009). Chondroitin sulfate is a glycosaminoglycan similar in structure to hyaluronic acid and negatively charged.…”

Section: Cs and Growth Factor Release From Contact Lensesmentioning

confidence: 99%

Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions

Sandri

Bonferoni

Delfino

et al. 2016

International Journal of Pharmaceutics

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Section: Cs and Growth Factor Release From Contact Lensesmentioning

confidence: 99%

Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions

Sandri

Bonferoni

Delfino

et al. 2016

International Journal of Pharmaceutics

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“…Stains All dye binds with glycosaminoglycans and forms complexes (blue colour) whose optical properties are different from those of the free dye (purple colour). [4] Stock solution of HA (100 μg/ml) was prepared in deionized water. Stains All dye (0.1 mg/ml) was prepared in solvent mixture of deionized water: methanol (80:20 ratio).…”

Section: Analysis Of Ha Using Stains All Dyementioning

confidence: 99%

“…[1][2][3] Treatment includes the use of rewetting solutions, lubricants, comfort agents, or artificial tears via eye drops to stabilize the tear film. [4] The main disadvantage of using the eye drops is their low residence time (less than 5 min), which needs frequent instillations, affecting quality of life. [5][6][7] Thus, there is a great need for extended delivery of comfort enhancing agent devices to treat dry eye syndrome.…”

Section: Introductionmentioning

confidence: 99%

Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome

Maulvi

Soni

Shah

2015

Journal of Biomaterials Science, Polymer Edition

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Current dry eye treatment includes delivering comfort enhancing agents to the eye via eye drops, but low residence time of eye drops leads to low bioavailability. Frequent administration leads to incompliance in patients, so there is a great need for medical device such as contact lenses to treat dry eye. Studies in the past have demonstrated the efficacy of hyaluronic acid (HA) in the treatment of dry eyes using eye drops. In this paper, we present two methods to load HA in hydrogel contact lenses, soaking method and direct entrapment. The contact lenses were characterized by studying their optical and physical properties to determine their suitability as extended wear contact lenses. HA-laden hydrogel contact lenses prepared by soaking method showed release up to 48 h with acceptable physical and optical properties. Hydrogel contact lenses prepared by direct entrapment method showed significant sustained release in comparison to soaking method. HA entrapped in hydrogels resulted in reduction in % transmittance, sodium ion permeability and surface contact angle, while increase in % swelling. The impact on each of these properties was proportional to HA loading. The batch with 200-μg HA loading showed all acceptable values (parameters) for contact lens use. Results of cytotoxicity study indicated the safety of hydrogel contact lenses. In vivo pharmacokinetics studies in rabbit tear fluid showed dramatic increase in HA mean residence time and area under the curve with lenses in comparison to eye drop treatment. The study demonstrates the promising potential of delivering HA through contact lenses for the treatment of dry eye syndrome.

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“…Thus, the amount of HA was determined by complexing with SA as reported by Fagnola et al [12]. Briefly, HA aqueous solutions were prepared with a concentration ranging from 0.3 to 5 mg/ml.…”

Section: Determination Of Ha By Colorimetric Assaymentioning

confidence: 99%

Combination of elastic liposomes and low frequency ultrasound for skin permeation enhancement of hyaluronic acid

Kasetvatin

Rujivipat

Tiyaboonchai

2015

Colloids and Surfaces B: Biointerfaces

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Hyaluronic acid in hydrophilic contact lenses: Spectroscopic investigation of the content and release in solution

Cited by 46 publications

References 23 publications

Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions

Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions

Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome

Combination of elastic liposomes and low frequency ultrasound for skin permeation enhancement of hyaluronic acid

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