Hyaluronic acid in otology: Its uses, advantages and drawbacks - A review

Daou, Christophe Abi Zeid; Bassim, Marc K.

doi:10.1016/j.amjoto.2019.102375

Cited by 19 publications

(19 citation statements)

References 56 publications

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“…Due to its anti-inflammatory and tissue regeneration properties, HA has been used for gene delivery in otology and there are some promising results in tympanic membrane perforation treatment [ 68 , 69 ].…”

Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

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This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects.

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Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

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“…Gradually, the adhesive changes of the eardrum develop and the middle ear bones are fixed. The condition can progress to chronic otitis with cholesteatoma (Abi Zeid Daou & Bassim, 2020). Current studies also show that therapeutic intranasal administration of hyaluronic acid significantly improves the course of otitis media with effusion (Cioffi et al, 2017;Topazio D et al, 2019;Torretta et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Due to its unique viscoelastic nature and non-immunogenicity, HA can also be used in a number of clinical applications, including joint fluid supplementation in osteoarthritis, to facilitate healing and regeneration of surgical wounds, as well as in ophthalmology, pharmacology, and cosmetics (Kotaška & Trč, 2018). Current studies describe the use of hyaluronic acid as an important drug in otitis media effusion due to its anti-inflammatory and draining (mucociliar clearance) characteristics and for its ability to protect the mucous membranes (Abi Zeid Daou & Bassim, 2020;Deng et al, 2018;Torretta et al, 2017;Torretta et al, 2016). Otitis media effusion is a non-inflammatory disease characterized by the presence of fluid of different viscosities in the middle ear and conductive hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid concentration in the middle ear fluid as an indicator of severity of the secretory otitis in newborns with cleft palate

et al. 2021

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The aim of the study was to investigate the hyaluronic acid concentration in middle ear fluid of patients with cleft palate as an indicator of the severity of the disease. Hyaluronic acid was examined in the middle ear fluid of 65 children (48 boys and 17 girls) subjected to cleft lip surgery in neonatal period up to 10 days of age. Patients were divided into 3 groups according to the course of the disease. First group consists of 15 patients with favorable course, second group consist of 25 patients with moderate course, third group included 25 patients with an adverse course. Hyaluronic acid levels were determined by commercially available immunoassay. The concentrations of hyaluronic acid in the middle ear fluid were as follows (mean+SEM): favorable course: 14253+2393 µg/l, moderate course: 7503+1345 µg/l, adverse course: 5905+2393 µg/l. Patients with adverse course and moderate course had significantly decreased hyaluronic acid levels in middle ear fluid compared to the patients with favorable course (P=0.02 and P=0.0018). Hyaluronic acid concentration is related to the course of the disease and the lowest values are most frequent in patients with an adverse course.

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“…A comprehensive review by Daou et al [ 39 ] explored the application of Hyaluronic acid (HA) in otology. This review highlighted HA to be generally safe, biocompatible, and degradable in the middle ear, without eliciting a foreign body reaction; it is also stated that its use in stapes surgery decreases postoperative vestibular symptoms and has no significant ototoxicity.…”

Section: Discussionmentioning

confidence: 99%

Comparison of different oval window sealing materials in stapes surgery: systematic review and meta-analysis

Scarpa

Marra

Ralli

et al. 2022

Eur Arch Otorhinolaryngol

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Objective To compare the efficacy and safety characteristics of different materials used for oval window sealing during stapedotomy. Methods A systematic review was conducted according to the PRISMA guidelines. Published international English literature from January 1, 2000 to December 2021 was screened, checking for studies that compared different materials utilization in patients undergoing stapedotomy surgery for otosclerosis or congenital stapes fixation. Data related to the efficacy and safety of each material were extracted. The primary outcome measure was the air–bone gap (ABG) closure after surgical intervention. Results Six studies were included in the metanalysis. Because of the heterogeneity of the treatments adopted, we assessed the use of the fat compared to all other treatments, and the use of the gelfoam compared to all other treatments. In the former analysis (fat vs others) we did not identify differences in ABG closure between the groups (p = 0.74), with a low heterogeneity of the results (I2 = 28.36%; Hedge’s g = 0.04, 95% CI − 0.19 0.27); similarly, we did not identify differences between the use of gelfoam and other treatments (p = 0.97), with a low heterogeneity of the results (I2 = 28.91%; Hedge’s g = 0.00, 95% CI − 0.20 0.21). Conclusions Numerous options are available for oval window sealing during stapedotomy, with acceptable safety and effectiveness profiles. Based on the current data, no definitive recommendation can be made regarding the choice of one material over another, and the convenience of sealing over no sealing at all.

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Hyaluronic acid in otology: Its uses, advantages and drawbacks - A review

Cited by 19 publications

References 56 publications

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Hyaluronic acid concentration in the middle ear fluid as an indicator of severity of the secretory otitis in newborns with cleft palate

Comparison of different oval window sealing materials in stapes surgery: systematic review and meta-analysis

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