Hyaluronic acid modified bubble-generating magnetic liposomes for targeted delivery of doxorubicin

Jose, Gils; Lu, Yu-Jen; Chen, Huai-An; Hsu, Heng-Jung; Hung, Jung‐Tung; Anilkumar, T.; Chen, Jyh‐Ping

doi:10.1016/j.jmmm.2018.11.019

Cited by 33 publications

(20 citation statements)

References 37 publications

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“…Bubble-generating magnetic liposomal (BML) drug delivery system is triggered with drug release properties for targeted delivery of doxorubicin in cancer therapy. BML was obtained by treatment of liposomes with citric acid-coated iron oxide MNPs co-entrapped with ammonium bicarbonate by simple hydration and surface modified with hyaluronic acid-polyethylene glycol (HA-PEG) coating [109]. The resultant liposomes are effective in delivering increased DOX concentration to the human glioblastoma cells (U87) cancer cells through temperature-sensitive drug release thereby improving targeting as well as treatment efficiency.…”

Section: Physical Properties Of Nanoparticlementioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.

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Section: Physical Properties Of Nanoparticlementioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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“…FTIR spectra of samples are shown in Figure 2 A. Amino-modified magnetic nanoparticles (AMNPs) showed a strong characteristic absorption peak at 578 cm −1 (asymmetric stretching vibration peak of Fe–O) [ 24 ], while transmissions around 1629 cm −1 and 3425 cm −1 could be assigned to the N–H stretching and bending vibrations of free –NH 2 , respectively [ 25 ], confirming the successful synthesis of AMNPs. The FTIR spectrum of blank liposomes displayed absorption peaks at 1090 and 1236 cm −1 , attributed to symmetric and asymmetric –PO 2 stretching vibrations; at 1467 cm −1 , assigned to –CH 2 bending vibration; and at around 2853 and 2924 cm −1 , attributed to symmetric and asymmetric –CH 2 stretching vibrations in the acyl chain [ 21 ], respectively. It should be noted that all the characteristic peaks of blank liposomes and AMNPs were observed in the spectrum of BMLs, which confirmed the successful encapsulation of AMNPs in BMLs.…”

Section: Resultsmentioning

confidence: 99%

“…The magnetic hysteresis loops of AMNPs and BMLs, measured by vibrating sample magnetometer (VSM) at room temperature, are shown in Figure 2 D. No magnetic hysteresis was observed in magnetization curves, suggesting that AMNPs and BMLs exhibited superparamagnetic properties. Generally, the covering of phospholipid on the surface of AMNPs would decrease the saturation magnetization [ 21 ]. As expected, the saturation magnetization value of BMLs (9 emu/g) was lower than that of AMNPs (27 emu/g).…”

Section: Resultsmentioning

confidence: 99%

“…NH 4 HCO 3 can produce CO 2 bubbles upon heat treatment, which bestows liposomes with good temperature-triggered release properties [ 20 ]. By encapsulating NH 4 HCO 3 and MNPs into liposomes directly, BMLs were prepared for targeted drug delivery [ 21 , 22 ]. Inspired by the above research, we developed a strategy based on BMLs that integrated features of capturing fat-soluble compounds into the lipid layer, magnetic separation from impurities by a magnetic field, and thermo-responsive controlled release of captured compounds to quickly screen the biomembrane-permeable compounds in herbal medicines.…”

Section: Introductionmentioning

confidence: 99%

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Fast Screening of Biomembrane-Permeable Compounds in Herbal Medicines Using Bubble-Generating Magnetic Liposomes Coupled with LC–MS

Gu¹,

Wang²,

Wang³

et al. 2021

Molecules

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A novel strategy based on the use of bionic membrane camouflaged magnetic particles and LC–MS was developed to quickly screen the biomembrane-permeable compounds in herbal medicines. The bionic membrane was constructed by bubble-generating magnetic liposomes loaded with NH4HCO3 (BMLs). The lipid bilayer structure of the liposomes enabled BMLs to capture biomembrane-permeable compounds from a herbal extract. The BMLs carrying the compounds were then separated from the extract by a magnetic field. Upon heat treatment, NH4HCO3 rapidly decomposed to form CO2 bubbles within the liposomal bilayer, and the captured compounds were released from BMLs and analyzed by LC–MS. Jinlingzi San (JLZS), which contains various natural ingredients, was chosen to assess the feasibility of the proposed method. As a result, nine potential permeable compounds captured by BMLs were identified for the first time. Moreover, an in vivo animal study found that most of the compounds screened out by the proposed method were absorbed into the blood. The study provides a powerful tool for rapid and simultaneous prediction of multiple biomembrane-permeable components.

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“…The saturation magnetization value of MLs is lower than that of CMNPs (13.0 emu/g). The drop in magnetization strength may be associated with encapsulation of CMNPs within the liposomes, as the magnetization sensitivity may decline when the surfaces of CMNPs are occupied by lipids [ 43 , 44 ]. Nonetheless, decreased saturation magnetization may largely stem from the reduced weight percentage of CMNPs in MLs, as the magnetic moment is based on the unit weight of MLs, while all other components in MLs are diamagnetic [ 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Optimization of the Preparation of Magnetic Liposomes for the Combined Use of Magnetic Hyperthermia and Photothermia in Dual Magneto-Photothermal Cancer Therapy

Anilkumar

Chen

2020

IJMS

Self Cite

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In this work, we aimed to develop liposomal nanocomposites containing citric-acid-coated iron oxide magnetic nanoparticles (CMNPs) for dual magneto-photothermal cancer therapy induced by alternating magnetic field (AMF) and near-infrared (NIR) lasers. Toward this end, CMNPs were encapsulated in cationic liposomes to form nano-sized magnetic liposomes (MLs) for simultaneous magnetic hyperthermia (MH) in the presence of AMF and photothermia (PT) induced by NIR laser exposure, which amplified the heating efficiency for dual-mode cancer cell killing and tumor therapy. Since the heating capability is directly related to the amount of entrapped CMNPs in MLs, while the liposome size is important to allow internalization by cancer cells, response surface methodology was utilized to optimize the preparation of MLs by simultaneously maximizing the encapsulation efficiency (EE) of CMNPs in MLs and minimizing the size of MLs. The experimental design was performed based on the central composite rotatable design. The accuracy of the model was verified from the validation experiments, providing a simple and effective method for fabricating the best MLs, with an EE of 87% and liposome size of 121 nm. The CMNPs and the optimized MLs were fully characterized from chemical and physical perspectives. In the presence of dual AMF and NIR laser treatment, a suspension of MLs demonstrated amplified heat generation from dual hyperthermia (MH)–photothermia (PT) in comparison with single MH or PT. In vitro cell culture experiments confirmed the efficient cellular uptake of the MLs from confocal laser scanning microscopy due to passive accumulation in human glioblastoma U87 cells originated from the cationic nature of MLs. The inducible thermal effects mediated by MLs after endocytosis also led to enhanced cytotoxicity and cumulative cell death of cancer cells in the presence of AMF–NIR lasers. This functional nanocomposite will be a potential candidate for bimodal MH–PT dual magneto-photothermal cancer therapy.

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Hyaluronic acid modified bubble-generating magnetic liposomes for targeted delivery of doxorubicin

Cited by 33 publications

References 37 publications

Therapeutic efficacy of nanoparticles and routes of administration

Therapeutic efficacy of nanoparticles and routes of administration

Fast Screening of Biomembrane-Permeable Compounds in Herbal Medicines Using Bubble-Generating Magnetic Liposomes Coupled with LC–MS

Optimization of the Preparation of Magnetic Liposomes for the Combined Use of Magnetic Hyperthermia and Photothermia in Dual Magneto-Photothermal Cancer Therapy

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