Hyaluronic acid/platelet rich plasma-infused core-shell nanofiber membrane to prevent postoperative tendon adhesion and promote tendon healing

Chen, Chih‐Hao; Chen, Shih-Hsien; Chen, Shih‐Heng; Chuang, Andy Deng-Chi; Darshan, T.G.; Chen, Jyh‐Ping

doi:10.1016/j.ijbiomac.2023.123312

Cited by 17 publications

(5 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It could be because adding PRP to a polymer solution alters its viscosity, surface tension, and interfacial tension between its PGS and PLA components. Pore size and porosity may be affected by each of these variables 39 . The PRP-containing samples lead to improved cell adherence on the surface due to their much greater pore size and porosity value compared to PGS/PLA scaffold.…”

Section: Resultsmentioning

confidence: 99%

Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study

Heydari,

Zargar Kharazi,

Shariati

2024

Sci Rep

View full text Add to dashboard Cite

Novel wound dressings with therapeutic effects are being continually designed to improve the wound healing process. In this study, the structural, chemical, physical, and biological properties of an electrospun poly glycerol sebacate/poly lactide acid/platelet-rich plasma (PGS/PLA-PRP) nanofibers were evaluated to determine its impacts on in vitro wound healing. Results revealed desirable cell viability in the Fibroblast (L929) and macrophage (RAW-264.7) cell lines as well as human umbilical vein endothelial cells (HUVEC). Cell migration was evident in the scratch assay (L929 cell line) so that it promoted scratch contraction to accelerate in vitro wound healing. Moreover, addition of PRP to the fiber structure led to enhanced collagen deposition (~ 2 times) in comparison with PGS/PLA scaffolds. While by addition PRP to PGS/PLA fibers not only decreased the expression levels of pro-inflammatory cytokines (IL-6 and TNF-α) in RAW-264.7 cells but also led to significantly increased levels of cytokine (IL-10) and the growth factor (TGF-β), which are related to the anti-inflammatory phase (M2 phenotype). Finally, PGS/PLA-PRP was found to induce a significant level of angiogenesis by forming branching points, loops, and tubes. Based on the results obtained, the PGS/PLA-PRP dressing developed might be a promising evolution in skin tissue engineering ensuring improved wound healing and tissue regeneration.

show abstract

Section: Resultsmentioning

confidence: 99%

Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study

Heydari,

Zargar Kharazi,

Shariati

2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Many drugs and bioactive substances like growth factors, antibiotics, DNA, and proteins, could be introduced effectively into the core, which was enclosed by the shell fragment, and a prolonged release of these substances from the structure of core/shell nanofibers might result over time [70]. Chen et al (2023) produced core-shell nanofiber membranes include hyaluronic acid (HA) and platelet-rich plasma (PRP) [71].…”

Section: Yılmaz Et Al (mentioning

confidence: 99%

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Parın

2024

JIENS

View full text Add to dashboard Cite

Drug delivery systems perform to improve the drug's efficacy and heal the affected region. Electrospun nanofibers are strong drug carriers as a scaffold due to their high specific surface area, easy processing, lightweight material. Fibrous scaffolds encapsulating functional bioactive agents are important for drug delivery applications, and they show higher encapsulation efficiency and higher drug loading capacity than various types of carrier materials such as hydrogels, micro/nanobeads, films, conventional fibers, and sponges. In comparison to conventional electrospinning, bi-component electrospinning where drug loading does not occur largely on the surface of the polymer matrix, core-shell nanofibers showed delayed release and a decrease in burst release because the drug was loaded into the core layer. The purpose of this mini-review is to investigate the production and applications of the drug-loaded bi-component nanofibers in structure core-shell, side-by-side, hollow nanofibers, and also emulsion nanofibers using co-axial nozzles. Further, the parameters which influence of these electrospinning process, such as working conditions and polymer properties, as well as drug delivery profile of the resulting nanofibers, have been outlined briefly. The limited clinical studies on the nanofibers have been discussed. Eventually, perspectives on the problems, possibilities, and new approaches for electrospinning advancements have been presented, as well.

show abstract

“…Membrane nanocomposites fabricated by coaxial electrospinning techniques are generally known as appropriate vehicles for the delivery of various therapeutic cargoes to desired locations. Concerning postsurgical adhesions, a series of core-shell nanofibrous membranes were prepared in which HA/platelet-rich plasma (PRP) and PCL serve as the core and shell of electrospun nanocomposites, respectively [ 140 ]. PRP is a rich source of bioactive molecules (e.g., growth factors TGF-β1, PDGF, FGF-2) that can help accelerate wound healing (e.g., tendon recovery after tendon injury).…”

Section: Biocompatible Nanocomposites: New Players In Postoperative A...mentioning

confidence: 99%

Biocompatible Nanocomposites for Postoperative Adhesion: A State-of-the-Art Review

Kargozar,

Gorgani,

Nazarnezhad

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

To reduce and prevent postsurgical adhesions, a variety of scientific approaches have been suggested and applied. This includes the use of advanced therapies like tissue-engineered (TE) biomaterials and scaffolds. Currently, biocompatible antiadhesive constructs play a pivotal role in managing postoperative adhesions and several biopolymer-based products, namely hyaluronic acid (HA) and polyethylene glycol (PEG), are available on the market in different forms (e.g., sprays, hydrogels). TE polymeric constructs are usually associated with critical limitations like poor biocompatibility and mechanical properties. Hence, biocompatible nanocomposites have emerged as an advanced therapy for postoperative adhesion treatment, with hydrogels and electrospun nanofibers among the most utilized antiadhesive nanocomposites for in vitro and in vivo experiments. Recent studies have revealed that nanocomposites can be engineered to generate smart three-dimensional (3D) scaffolds that can respond to different stimuli, such as pH changes. Additionally, nanocomposites can act as multifunctional materials for the prevention of adhesions and bacterial infections, as well as tissue healing acceleration. Still, more research is needed to reveal the clinical potential of nanocomposite constructs and the possible success of nanocomposite-based products in the biomedical market.

show abstract

Hyaluronic acid/platelet rich plasma-infused core-shell nanofiber membrane to prevent postoperative tendon adhesion and promote tendon healing

Cited by 17 publications

References 69 publications

Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study

Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Biocompatible Nanocomposites for Postoperative Adhesion: A State-of-the-Art Review

Contact Info

Product

Resources

About