Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy

Sun, Qianqian; Bi, Huiting; Wang, Zhao; Li, Chunxia; Wang, Xuwei; Xu, Jiating; Zhu, Hui; Zhao, Ruoxi; He, Fei; Gai, Shili; Yang, Piaoping

doi:10.1016/j.biomaterials.2019.119473

Cited by 202 publications

(126 citation statements)

References 60 publications

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“…In addition, HA can actively target certain tumor cells and bind to the over-expressed CD44 receptor on the surface of tumor cells. 75,76 Li et al synthesized the ZIF-8/HA (ZIF-8 nanocomposite coated with HA) and loaded curcumin (CCM) to synthesize CCM@ZIF-8/HA for cancer treatment. Hydrophilic HA can recognize and bind to the over-expressed CD44 receptor on tumor cells, giving CCM@ZIF-8/HA active targeting ability.…”

Section: Zif-8@mesoporous Nanoparticle Compositesmentioning

confidence: 99%

“…When HA/ a-TOS@ZIF-8 reaches the tumor site, the hyaluronidase (HAase) in the tumor microenvironment can decompose the HA outer layer, then the exposed a-TOS@ZIF-8 will rapidly degrade under acidic conditions, releasing the drug a-TOS for tumor treatment. 76 The galactose derivative (G) has a high affinity for hepatoma cells (HepG2) that over-expressed galactagglutinin, and the galactosylation of drug-loaded ZIF-8 could produce better targeting effects on hepatoma cells. 77 Yang et al rst synthesized DOX-loaded ZIF-8 (ZIF-8@DOX) by a one-pot method, and then the water-soluble carboxylated pillar [6] arene (WP6) was used as modiers.…”

Section: Zif-8@mesoporous Nanoparticle Compositesmentioning

confidence: 99%

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Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

et al. 2020

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Section: Zif-8@mesoporous Nanoparticle Compositesmentioning

confidence: 99%

Section: Zif-8@mesoporous Nanoparticle Compositesmentioning

confidence: 99%

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

et al. 2020

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“…[22] This strategy leverages the affinity of biomacromolecules for metal ions, enabling the rapid and convenient onestep embedding of these macromolecules within MOFs by stimulating zeolitic imidazolate framework-8 (ZIF-8) growth. [23][24][25][26][27][28] This strategy effectively shields the packaged biomacromolecules with a porous "armor-like" ZIF-8 exoskeleton that shields them from denaturation while allowing for their selective transport through the accessible porous network. This ZIF-8 exoskeleton is highly stable and exhibits minimal toxicity in physiological contexts, whereas it breaks down when exposed to lower intratumoral pH levels.…”

Section: Introductionmentioning

confidence: 99%

Development of MOF “Armor‐Plated” Phycocyanin and Synergistic Inhibition of Cellular Respiration for Hypoxic Photodynamic Therapy in Patient‐Derived Xenograft Models

Chen

Suo

Jiang

et al. 2020

Adv Healthcare Materials

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Significant progress has been made in the use of phycocyanin (PC) as a photosensitizer (PS) agent for photodynamic therapy (PDT). The clinical use of PC, however, has been limited by its poor stability, unfavorable pharmacokinetics, limited tumor cell uptake, and the hypoxic nature of the tumor microenvironment. In this study, a novel biomimetic mineralization approach is described for encapsulating PC using zeolitic imidazolate framework-8 (ZIF-8), after which MPEG 2000-COOH is further utilized as an anchor on the ZIF/PC complex in order to yield MPEG 2000-ZIF/PC composites (PMs). These PMs are then used as a stable reinforced PS for PDT, effectively improving the intracellular delivery of this protein PS. In contrast to prior studies that have sought to overcome intratumoral hypoxia via increasing oxygen delivery to the tumor site, the mitochondrial complex I inhibitor papaverine (PPV) is instead utilized to reduce intratumor oxygen consumption in an effort to augment the PDT efficacy of the PMs. It is found that this combination treatment strategy markedly improves the antitumor properties of these PMs both in vitro and in patient-derived xenograft (PDX) models without inducing significant side effects. It is therefore proposed that the "armor-plating" of protein PS agents with ZIF-8 in combination with PPV may be a promising approach to precision medicine-mediated tumor treatment.

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“…Depending on the chemical properties of cross-linkers, drug release in CCL micelles can be governed by several intracellular and/or extracellular factors. Recently, some publications reported the success of controlled drug release by utilizing physicochemical properties such as pH-responsive [ 15 , 16 , 17 ], redox-responsive [ 18 , 19 ], temperature-responsive [ 20 , 21 , 22 ], and even light-responsive [ 23 , 24 ]. In fact, stable polymeric micelles with responsive release ability are now critically demanded as drug delivery materials.…”

Section: Introductionmentioning

confidence: 99%

Diselenide Core Cross-Linked Micelles of Poly(Ethylene Oxide)-b-Poly(Glycidyl Methacrylate) Prepared through Alkyne-Azide Click Chemistry as a Near-Infrared Controlled Drug Delivery System

et al. 2020

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In this article, a drug delivery system with a near-infrared (NIR) light-responsive feature was successfully prepared using a block copolymer poly(ethylene oxide)-b-poly(glycidyl methacrylate)-azide (PEO-b-PGMA-N3) and a cross-linker containing a Se-Se bond through “click” chemistry. Doxorubicin (DOX) was loaded into the core-cross-linked (CCL) micelles of the block copolymer along with indocyanine green (ICG) as a generator of reactive oxygen species (ROS). During NIR light exposure, ROS were generated by ICG and attacked the Se-Se bond of the cross-linker, leading to de-crosslinking of the CCL micelles. After NIR irradiation, the CCL micelles were continuously disrupted, which can be a good indication for effective drug release. Photothermal analysis showed that the temperature elevation during NIR exposure was negligible, thus safe for normal cells. In vitro drug release tests demonstrated that the drug release from diselenide CCL micelles could be controlled by NIR irradiation and affected by the acidity of the environment.

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Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy

Cited by 202 publications

References 60 publications

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

Development of MOF “Armor‐Plated” Phycocyanin and Synergistic Inhibition of Cellular Respiration for Hypoxic Photodynamic Therapy in Patient‐Derived Xenograft Models

Diselenide Core Cross-Linked Micelles of Poly(Ethylene Oxide)-b-Poly(Glycidyl Methacrylate) Prepared through Alkyne-Azide Click Chemistry as a Near-Infrared Controlled Drug Delivery System

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