Hyaluronsyra i synovialvätska: VI. Effekt av intraartikulära hyaluron-syreinfektioner på symtom vid arthrittillstånd hos kapplöpningshäster

Functionalized Derivatives of Hyaluronic Acid Oligosaccharides: Drug Carriers and Novel Biomaterials

“…Currently, local injections of high MW native HA in its noninflammatory form into the joint are used in the treatment of osteoarthritis. Combinations of corticosteroids and native HA injections have been used in veterinary medicine for the treatment of joint dysfunction in race horses (26).…”

Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1

“…Intra-articular injections of corticosteroids and systemically administered nonsteroidal anti-inflammatory agents remain the mainstays of treatment for relief of OA pain in equine athletes with OA. [6][7][8] Intra-articular administration of corticosteroids rapidly resolves joint effusion, synovial inflammation, and articular pain. However, it remains controversial whether repeated use of corticosteroids, specifically MPA, can actually exacerbate the progression of OA while masking the clinical signs of disease.…”

“…Clinically, HA has been coadministered with corticosteroids in an effort to mitigate the untoward effects of OA and further reduce joint pain. Early studies 7,8 in racehorses have documented a reduction in synovial cartilage degradation products when HA is used in combination with corticosteroids. Furthermore, the loss of HA from cartilage, through decreased synthesis or increased catabolism, can result in reduced extracellular matrix PG retention.…”

Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis

“…Hyaluronic acid, gives the synovial fluid high viscoelastic properties, was thought to ensure the lubrication of cartilage in the 1950s, especially when associated with significantly decreased viscoelasticity of synovial fluid from OA patients [111,112]. Therefore, articular injection of high molecular weight HA (usually above 1 MDa) has been used to alleviate the symptoms of OA clinically as viscosupplementation.…”

“…Very recently, considering such biolubricants were articularly injected into the join of OA model rats, a new constructing method was reported in order to enhance the inject ability [111]. As shown in Figure 8, Methacrylate gelatin (GelMA) hydrogel microspheres were firstly prepared by microfluidic fabrication, then copolymer polymerized by the monomer methacrylate dopamine (DMA) and MPC was absorbed onto the surface o GelMA to generate biolubricants GelMA@DMA-MPC via the robust adhesiveness of do pamine.…”