Hybrid Alginate‐Based Cryogels for Life Science Applications

Barros, Alexandre A.; Quraishi, Sakeena; Martins, Marta; Gurikov, Pavel; Subrahmanyam, Raman; Смирнова, Ирина; Duarte, Ana Rita C.; Reis, Rui L.

doi:10.1002/cite.201600096

Cited by 18 publications

(8 citation statements)

References 52 publications

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“…This type of structure is common when the slow growth of crystals occurs, caused by slow freezing and slow drying process. A similar structure is reported for other pectin cryogel systems in literature [ 6 , 19 ] and for other biopolymer-based cryogels, such as alginate [ 21 , 22 ] and starch [ 23 , 24 ]. It is interesting to note that the structure is dense in samples that contain tert-butanol (P2 and P3).…”

Section: Resultssupporting

confidence: 83%

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

et al. 2022

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In this research, the pectin monoliths were prepared via the sol-gel process through different routes of crosslinking and additional freeze-drying. The crosslinking reaction was induced by the use of calcium ions in aqueous solutions and in alcohol/water solutions. The resulting pectin monoliths obtained by freeze-drying were macroporous with open cells, limited specific surface area, moderate mechanical stability and moderate biodegradation rate. The presence of alcohol in crosslinking solution significantly changed the morphology of final pectin monoliths, which was evidenced by the reduction of their pore size for one order. The specific surface area of pectin monoliths obtained through the calcium-water-alcohol route was 25.7 m2/g, the Young compressive modulus was 0.52 MPa, and the biodegradation rate was 45% after 30 days of immersion in compost media. Considering that pectin can be obtained from food waste, and its physical properties could be tailored by different crosslinking routes, the pectin monoliths could find wide application in the pharmaceutical, agricultural, medical and food industries, providing sustainable development concepts.

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Section: Resultssupporting

confidence: 83%

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

et al. 2022

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“…Such morphology stems from the fact that the porous structure of hydrogels undergoes considerable changes due to growth of ice crystals. It is known that freezing regimes have a great influence on the pore morphology [53,54]. To obtain mesoporous alginate with appreciable surface area, a special technique is required such as aforementioned sublimation of fine crystals of tert-butanol/water eutectic mixture [38].…”

Section: Drying Of Alginate Gelsmentioning

confidence: 99%

Non-Conventional Methods for Gelation of Alginate

Gurikov

Смирнова

2018

Gels

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108

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This review presents and critically evaluates recent advances in non-conventional gelation method of native alginate. A special focus is given to the following three methods: cryotropic gelation, non-solvent induced phase separation and carbon dioxide induced gelation. A few other gelation approaches are also briefly reviewed. Results are discussed in the context of subsequent freeze and supercritical drying. The methods are selected so as to provide the readers with a range of novel tools and tactics of pore engineering for alginate and other anionic polysaccharides.

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“…Aerogels can be produced from inorganic, organic, or organic-inorganic precursors, which gave them a flexible surface chemistry and allow them to be used in huge number of applications such as insulation, food technology, catalysis, environmental, and life sciences applications (Gurikov and Smirnova, 2017;Maleki, 2016;Maleki and Hüsing, 2018;Stergar and Maver, 2016;Ulker and Erkey, 2014). Being renewable, abundant, biodegradable, and biocompatible, polysaccharide-based aerogels have attracted increasingly attention in the field of tissue engineering and drug delivery (Barros et al, 2016;García-González et al, 2011;Martins et al, 2015;Obaidat et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Loading and evaluation of meloxicam and atorvastatin in carrageenan microspherical aerogels particles

2019

J App Pharm Sci

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In this work, the potential of using microspherical aerogel particles based on commercial carrageenan as a drug vehicle was evaluated. Carrageenan hydrogel microparticles were prepared following the emulsion gelation approach. After the successive solvent exchange, supercritical CO 2 drying procedure was employed to obtain aerogel microspherical particles. Meloxicam and atorvastatin (class II drug) were loaded into the aerogel matrix by adsorption from their corresponding supercritical CO 2 solution. All preparations were characterized by their physicochemical properties. In vitro drug released was investigated for the drug-aerogel formulation to assist the effect of aerogel technology on the release profile of the targeted drug. Meloxicam and atorvastatin model drugs maintained their crystalline structure. Significant enhancement in the release profile of meloxicam after loading in the carrageenan aerogel can be related to de-aggregation of meloxicam inside the particle, while no enhancement in atorvastatin release was observed. Results were indicative of a failure in the loading of atorvastatin inside the carrageenan particle at the selected experimental processing parameters.

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Hybrid Alginate‐Based Cryogels for Life Science Applications

Cited by 18 publications

References 52 publications

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

Non-Conventional Methods for Gelation of Alginate

Loading and evaluation of meloxicam and atorvastatin in carrageenan microspherical aerogels particles

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