Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?

Oliveira, Felipe Ladeira de; Silveira, Luisa Kelmer Côrtes de Barros; Machado, Adriana Rodrigues; Nery, José Augusto da Costa

doi:10.1155/2012/102915

Cited by 7 publications

(8 citation statements)

References 15 publications

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“…Elastolysis may be seen in granuloma annulare, but the complete loss of elastic fibers in the central area is characteristic of AEGCG (4,8,9). Furthermore, a hybrid pattern has been described, indicating an overlap between AEGCG and granuloma annulare (10). Consequently, histopathology of the our cases were consistent with the literature by the presence of the foreign body type multinuclear giant cells, lymphocytic cell infiltration, elastophagocytosis and the absence of solar elastosis, necrobiosis and mucin deposition.…”

Section: Discussionsupporting

confidence: 89%

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Erdoğan¹,

Arık²,

Acer³

et al. 2018

tdd

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Objective: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous disease characterized by annular plaques. In this study, we aimed to describe the clinical and pathological features of the patients diagnosed with AEGCG. Methods: The demographic, clinical and pathological features of patients who diagnosed with AEGCG were recorded retrospectively. Results: Ten patients with AEGCG included in the study (nine females and one male). The mean age of the patients was 60±9.53 years. The mean duration of disease was 24.2±36.30 months. On dermatologic examination, multiple, well-demarcated, elevated borders and central atrophic erythematous annular plaques were seen in all patients. In the most of the patients (90%) lesions were on the sun-exposed regions. Six of the patients had accompanying diseases. Histopathologic examination of the punch biopsies revealed foreign body type multinucleated giant cells and lymphocytic cell infiltration in the dermis. There were intracellular elastic fiber fragments as sign of elastophagocytosis in the giant cells. Conclusion: AEGCG is a rare granulomatous disease which can accompany various diseases. There is debate on the terminology, classification and pathogenesis. Further studies are required to elucidate the unknowns.Amaç: Anüler elastolitik dev hücreli granülom (AEDHG), anüler plaklar ile karakterize, nadir granülomatöz bir hastalıktır. Bu çalışmada AEDHG tanısı konulan hastaların klinik ve patolojik özelliklerini tanımlamayı amaçladık. Yöntemler: AEDHG tanısı konulan hastaların demografik, klinik ve patolojik özellikleri retrospektif olarak kaydedildi. Bulgular: Çalışmaya AEDHG tanısı konulan 10 hasta dahil edildi (9 kadın, 1 erkek). Hastaların yaş ortalaması 60±9,53 yıldı. Ortalama hastalık süresi 24,2±36,30 aydı. Dermatolojik muayenede tüm hastalarda multipl, iyi sınırlı, sınırları kabarık ve ortası atrofik, eritemli anüler plaklar vardı. Hastaların çoğunda (%90) lezyonlar güneş gören bölgelerdeydi. Hastaların 6'sında eşlik eden hastalık mevcuttu. Punch biyopsilerin histopatolojik incelemesinde dermiste yabancı cisim tipi multinükleer dev hücreler ve lenfositik hücre infiltrasyonu görüldü. Dev hücrelerde elastofagositozun işareti olan intraselüler elastik lif parçaları vardı. Sonuç: AEGCG çeşitli hastalıklara eşlik edebilen, nadir granülomatöz bir hastalıktır. Terminoloji, sınıflandırma ve patogenezinde tartışma vardır. Bilinmeyenleri açıklığa kavuşturmak için daha ileri çalışmalara ihtiyaç vardır. Anahtar kelimeler: Anüler elastolitik dev hücreli granülom, elastofagositoz, granülomatöz hastalıklar, elastoliz, dev hücre, granüloma anülare Öz

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Section: Discussionsupporting

confidence: 89%

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Erdoğan¹,

Arık²,

Acer³

et al. 2018

tdd

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“…Fumaric acid esters have also been successfully used, with mild adverse effects. 79,80 Hydroxychloroquine [81][82][83][84] and chloroquine 20,26 have also shown positive results, although there are also cases with no response to antimalarials. 12 Failure to isotretinoin, 85 methotrexate, 73 PUVA, 51,69 and cryotherapy 86 has also been reported.…”

Section: Evaluation and Managementmentioning

confidence: 99%

Elastolytic Actinic Giant Cell Granuloma

Gutiérrez‐González

Pereiro

Toribio

2015

Dermatologic Clinics

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“…Annular elastolytic giant cell granuloma is an uncommon dermatological condition firstly described by Hanke et al as annular lesions associated with a granulomatous elastolytic pattern (8,9). It usually appears in sun-exposed areas, such as the face and neck, and is rarely seen on the trunk, back and extremities (9).…”

Section: Discussionmentioning

confidence: 99%

“…It usually appears in sun-exposed areas, such as the face and neck, and is rarely seen on the trunk, back and extremities (9). The majority of cases occur in middle-aged Caucasian women.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that cellular immunological reactions induced by modified function of antigenicity of elastic fibres play a role in the mechanism of AEGCG formation, and ultraviolet radiation may be responsible for the antigenicity of elastic fibres (9). The disease can accompany some endocrine and tumoral diseases such as diabetes mellitus (8,9), solid organ tumours and haematologic malignancy (8) as in GA. On the other hand, it has been suggested that some granulomatous diseases such as GA and interstitial granulomatous dermatitis might be partly caused by B burgdorferi or similar strains (2,10). The presence of activated T-cells in the lymphocytic infiltrate of GA has been demonstrated, suggesting there is a cellmediated immune response to various precipitating factors (3).…”

Section: Discussionmentioning

confidence: 99%

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Treatment of Generalized Annular Elastolytic Giant Cell Granuloma with Doxycycline which is Associated with Borrelia burgdorferi Infection

2015

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This is a case of generalized annular elastolytic giant cell granuloma (AEGCG) associated with borrelia infection and genes of p-30, p-31, p-39 RESUMEN Se trata de un caso de granuloma elastolítico anular de células gigantes (GEACG) generalizado, asociado con infección por Borrelia y con los genes de p-30, p-31, p-39. Una posible reacción transmediada del tipo de célula T que podría haber inducido la GEACG, se discute a partir del concepto de "proteínas de shock térmico (PST) y mímica molecular".Palabras claves: Granuloma anular elastolítico de células gigantes, Borrelia burgdorferi, proteínas de shock térmico, enfermedad de Lyme, mímica molecular West Indian Med J 2015; 64 (4): 447From:

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Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?

Cited by 7 publications

References 15 publications

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Elastolytic Actinic Giant Cell Granuloma

Treatment of Generalized Annular Elastolytic Giant Cell Granuloma with Doxycycline which is Associated with Borrelia burgdorferi Infection

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