In order to explore the application of deep learning based intelligent imaging technology in the diagnosis of colorectal cancer, Tangdu Hospital patients are selected as the research object in this study. By scanning the cancer sites, then distinguishing and extracting the features of the tumors, the collected data are input into the designed in-depth learning intelligent assistant diagnosis system for comparison. The results show that in the analysis of image prediction accuracy, the best prediction accuracy of T1-weighted image method is matrix GLCM (gray level co-occurrence matrix) algorithm, the best prediction accuracy of adding T1-weighted image method is matrix MGLSZM (multi-gray area size matrix) algorithm, and the best prediction accuracy of T2-weighted image method is ALL combination of all texture features, and the best prediction accuracy of three imaging sequences is not more than 0.8. In the AUC analysis of the area under the curve of different texture features, it is found that T2-weighted imaging method has obvious advantages in differentiating colorectal cancer from other methods. Therefore, through this study, it is found that in the use of deep learning intelligent assistant diagnosis system for the diagnosis of colorectal cancer, it can provide useful information for the clinical diagnosis of colorectal cancer to a certain extent. Although there are some deficiencies in the research process, it still provides experimental basis for the diagnosis and treatment of colorectal cancer in later clinical stage.INDEX TERMS Deep learning, colorectal cancer, weighted images, accuracy, texture features.