Hybrid dextran-iron oxide thin films deposited by laser techniques for biomedical applications

Predoi, Daniela; Ciobanu, Carmen Steluţa; Radu, Mihaela; Costache, Marieta; Dinischiotu, Anca; Popescu, C.; Axente, E.; Mihăilescu, I. N.; György, E.

doi:10.1016/j.msec.2011.10.032

Cited by 20 publications

(24 citation statements)

References 28 publications

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“…This observation is in good agreement with SAED analysis indicating that the NPs' crystalline phase was preserved during laser processing. Moreover, the average size <d> of the nanocrystalites computed using Scherrer's formula [112] evidenced values around 7.7 nm, in accordance with the average size of the NPs determined from HRTEM micrographs [18]. Figure 4 illustrates the structural characteristics of the coatings inferred by Fourier transform infrared spectroscopy (FTIR).…”

Section: Hybrid Dextran-iron Oxide Thin Filmssupporting

confidence: 72%

“…Furthermore, the intensity of the bands corresponding to the maghemite γ-Fe 2 O 3 phase increases with increasing NPs concentration in the composite targets used in MAPLE experiments. The typical surface morphology of thin films deposited by MAPLE technique is characterized by an aggregated structure, consisting of micrometer-sized particles [17,18,22,39,119]. It is worth noting that a larger specific surface area was proven to induce an enhanced bioactivity, able to promote osteoblast differentiation, as reported in case of hybrid organic-inorganic thin films deposited by MAPLE [120,121].…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 81%

“…Only NP concentrations below 100 μg/ml are considered safe [110]. The growth of hybrid thin films consisting of Dextran and maghemite γ-Fe 2 O 3 NPs using MAPLE technique was reported by Predoi and coworkers [18]. The authors investigated the biocompatibility, an essential requirement for the introduction of iron oxide into the human body, but also the influence of the NP concentration on the biomimetic properties of the synthesized coatings.…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

“…The biocompatibility of the Dextran-iron oxide thin films was demonstrated by 3-(4.5 dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide-based colorimetric assay, using human liver hepatocellular carcinoma (Hep G2) cell line [18]. In Figure 5 The results of the viability tests (MTT) of Hep G2 cells on pure Dextran drop-casted solution, Dextran and Dextran-iron oxide composite thin films obtained by MAPLE are presented in Figure 5.E, and compared to the cells cultivated on control samples (considered as having a viability of 100%).…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

“…As a biodegradable and biocompatible biopolymer, it was investigated as a blood plasma replacement in the early 1940s [38]. Dextran could be functionalized with nanoparticles [18,39,40] or conjugated with different polymers [41][42][43][44] for various biomedical applications as described in Section 4.1.…”

Section: Introductionmentioning

confidence: 99%

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Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic-inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries' synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.

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Section: Hybrid Dextran-iron Oxide Thin Filmssupporting

confidence: 72%

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 81%

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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MAPLE Deposition of Macromolecules

Shepard

Priestley

2013

Macro Chemistry & Physics

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Macromolecules are poised to feature prominently as components in organic electronics, medical implants, drug delivery systems, and sensors. A common theme for the role polymers will play in all of these is as a thin film. In all applications, it is paramount to have precise control over film thickness, structure, morphology, surfaces roughness, etc. Here, matrix‐assisted pulsed laser evaporation (MAPLE) is reviewed as a route to processing polymer and other soft matter thin films with control over the above‐mentioned parameters. After briefly discussing the experimental setup and current proposed mechanism of film formation via MAPLE, the use of MAPLE to process thin films is highlighted for use in various technologies and applications. Future directions and challenges for MAPLE processing of thin films are also discussed.magnified image

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Nanoarchitectonics Prepared by MAPLE for Biomedical Applications

Popescu

Grumezescu

2015

Green Processes for Nanotechnology

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Hybrid dextran-iron oxide thin films deposited by laser techniques for biomedical applications

Cited by 20 publications

References 28 publications

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

MAPLE Deposition of Macromolecules

Nanoarchitectonics Prepared by MAPLE for Biomedical Applications

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