Hybrid gadolinium oxide nanoparticles combining imaging and therapy

Nanoparticles Containing Rare Earth Ions: A Tunable Tool for MRI

“…Unloaded cells are also not affected by exposure to a thermal neutron beam if the delivered dose is equal to 3 Gy (or less). But the irradiation of EL4-luc cells after incubation in the presence of GadoSiPEG ([Gd] incubation = 0.05 mM) by harmless thermal neutron beam (3 Gy) generates a great killing effect since all cells are destroyed [136]. Gadolinium oxide cores embedded in a fluorescent and PEGylated polysiloxane shell are very attractive multifunctional nanostructures for in vivo application and, in particular, for imaging guided therapy since they combine fluorescence imaging (organic dyes conjugated to the inner part of the polysiloxane shell), MRI (gadolinium(III) ions in the crystalline core), and therapeutic activity, which exploits some properties of the gadolinium element (radiotherapy and neutron therapy).…”

“…Although the encapsulation of the gadolinium oxide cores by polysiloxane shell seems more difficult to control, it nevertheless allows enlarging more easily the palette of properties of the contrast agents since postfunctionalization of gadolinium oxide cores can be realized sequentially, in contrast to the encapsulation by organic acids. Besides MR imaging, which is efficient whatever the functionalization mode, GadoSiPEG nanoparticles can indeed be easily followed up by fluorescence imaging after their uptake by cells or after their intravenous injection into small animals [131,132,136,141], whereas the detection of PEGylated organic acid capped gadolinium oxide nanoparticles by fluorescence imaging rests only on the doping of the core by rare earth ions [140]. Despite its interesting properties, the fluorescence imaging based on the luminescence of rare earth ions (Tb 3+ ) is not very well suited for biological applications because the light emission of Tb 3+ in gadolinium oxide is induced by the absorption of UV photons, which are harmful for living matter.…”

D‐Glucuronic Acid Coated Gd(IO3)3·2H2O Nanomaterial as a Potential T1 MRI‐CT Dual Contrast Agent

“…[8][9][10] This study deals with a T 1 MRI-CT dual contrast agent. Multimodal imaging can be generally used to improve the accuracy of disease diagnoses.…”

Properties of the amorphous-nanocrystalline Gd2O3 powder prepared by pulsed electron beam evaporation

“…For the purpose to decrease the toxicity of Gd 2 O 3 nanoparticles and their aggregation in aqueous sus pensions, as well as to enhance contrasting properties, extensive investigations have been performed on Gd 2 O 3 nanoparticles covered with shells of various organic (polyethylene glycol [23], dextran [24], pol ysiloxane [25], diethylene glycol [26]) and inorganic (Gd 2 O 3 /SiO 2 [15]) substances. In particular, McDonald and Watkin [27] observed that small Gd 2 O 3 nanoparticles encapsulated in spherical albumin par ticles provided a better contrast than free Gd 2 O 3 parti cles and, in strong magnetic fields, retained their con trasting properties despite the observations of weaken ing these properties in other contrast agents [28].…”