Hybrid Imaging Worldwide—Challenges and Opportunities for the Developing World: A Report of a Technical Meeting Organized by IAEA

Kashyap, Ravi; Dondi, Maurizio; Páez, Diana; Mariani, Guliano

doi:10.1053/j.semnuclmed.2013.02.001

Cited by 19 publications

(8 citation statements)

References 34 publications

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“…Especially, given the greater number of patients with middle temporal discharges on EEG, the MRI-/PET+ group may likely represent patients with neocortical TLE. At any rate, although clinicians have to detect MRI-/PET+ TLE to identify surgical candidates, the availability of PET is still limited, particularly in developing countries ( Kashyap et al, 2013 ). In this context, it would be meaningful to reveal the potential of NODDI as a novel biomarker beyond conventional dMRI metrics in MRI-/PET+ TLE.…”

Section: Discussionmentioning

confidence: 99%

Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging

Sone

Ota

Maikusa

et al. 2018

NeuroImage: Clinical

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BackgroundDespite recent advances in diffusion MRI (dMRI), there is still limited information on neurite orientation dispersion and density imaging (NODDI) in temporal lobe epilepsy (TLE). This study aimed to demonstrate neurite density and dispersion in TLE with and without hippocampal sclerosis (HS) using whole-brain voxel-wise analyses.Material and methodsWe recruited 33 patients with unilateral TLE (16 left, 17 right), including 14 patients with HS (TLE-HS) and 19 MRI-negative 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)-positive patients (MRI-/PET+ TLE). The NODDI toolbox calculated the intracellular volume fraction (ICVF) and orientation dispersion index (ODI). Conventional dMRI metrics, that is, fractional anisotropy (FA) and mean diffusivity (MD), were also estimated. After spatial normalization, all dMRI parameters (ICVF, ODI, FA, and MD) of the patients were compared with those of age- and sex-matched healthy controls using Statistical Parametric Mapping 12 (SPM12). As a complementary analysis, we added an atlas-based region of interest (ROI) analysis of relevant white matter tracts using tract-based spatial statistics.ResultsWe found decreased neurite density mainly in the ipsilateral temporal areas of both right and left TLE, with the right TLE showing more severe and widespread abnormalities. In addition, etiology-specific analyses revealed a localized reduction in ICVF (i.e., neurite density) in the ipsilateral temporal pole in MRI-/PET+ TLE, whereas TLE-HS presented greater abnormalities, including FA and MD, in addition to a localized hippocampal reduction in ODI. The results of the atlas-based ROI analysis were consistent with the results of the SPM12 analysis.ConclusionNODDI may provide clinically relevant information as well as novel insights into the field of TLE. Particularly, in MRI-/PET+ TLE, neurite density imaging may have higher sensitivity than other dMRI parameters. The results may also contribute to better understanding of the pathophysiology of TLE with HS.

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Section: Discussionmentioning

confidence: 99%

Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging

Sone

Ota

Maikusa

et al. 2018

NeuroImage: Clinical

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“…In addition, strategies for dose reduction have been considered. There is high-technology hardware, such as CZT cameras, 20 , 21 which provide high image resolution, and hybrid devices, such as SPECT-CT, which can eliminate the attenuation of soft tissues, 22 but they are not widely available. A strategy that can be used without additional costs for those without attenuation correction is the prone position during the acquisition of the stress phase of MPS.…”

Section: Discussionmentioning

confidence: 99%

Current Practices in Myocardial Perfusion Scintigraphy in Brazil and Adherence to the IAEA Recommendations: Results of a Cross-Sectional Study

Rodrigues¹,

Oliveira

Wiefels³

et al. 2018

Arquivos Brasileiros De Cardiologia

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BackgroundData on the current situation of nuclear medicine practices in cardiology in Brazil are scarce. The International Atomic Energy Agency (IAEA) has recommended eight "good practices" to minimize patients' ionizing radiation exposure during myocardial perfusion scintigraphy (MPS).ObjectivesTo assess the adoption of the eight good practices in MPS in Brazil.MethodsCross-sectional study with data obtained by use of a questionnaire. All hypothesis tests performed considered a significance level of 5%.ResultsWe observed that 100% of the nuclear medicine services (NMS) assessed do not use thallium-201 as the preferred protocol. Regarding the use of technetium-99m, 57% of the NMS administer activities above the threshold recommended by the IAEA (36 mCi) or achieve an effective dose greater than 15 millisievert (mSv). The abbreviated stress-only myocardial perfusion imaging is not employed by 94% of the NMS; thus, only 19% count on strategies to reduce the radioactive doses. Approximately 52% of the NMS reported always performing dose adjustment for patient's weight, while 35% administer poorly calculated doses in the one-day protocol.ConclusionA considerable number of NMS in Brazil have not adopted at least six practices recommended by the IAEA. Despite the difficulties found in nuclear practice in some Brazilian regions, almost all obstacles observed can be overcome with no cost increase, emphasizing the importance of developing strategies for adopting "good practices" when performing MPS.

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“…The use of SPECT/CT is rising in frequency and spreading to new clinical settings. Recent trends in sales of new nuclear medicine equipment confirm that installations of SPECT/CT devices exhibit a steep surge worldwide [4].…”

Section: Introductionmentioning

confidence: 99%

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

Israel

Pellet

Biassoni

et al. 2019

Eur J Nucl Med Mol Imaging

169

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Purpose Single-photon emission computed tomography (SPECT) combined with computed tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago. The main advantage of SPECT/CT is the increased specificity achieved through a more precise localization and characterization of functional findings. The improved diagnostic accuracy is also associated with greater diagnostic confidence and better inter-specialty communication. Methods This review presents a critical assessment of the relevant literature published so far on the role of SPECT/CT in a variety of clinical conditions. It also includes an update on the established evidence demonstrating both the advantages and limitations of this modality. Conclusions For the majority of applications, SPECT/CT should be a routine imaging technique, fully integrated into the clinical decision-making process, including oncology, endocrinology, orthopaedics, paediatrics, and cardiology. Large-scale prospective studies are lacking, however, on the use of SPECT/CT in certain clinical domains such as neurology and lung disorders. The review also presents data on the complementary role of SPECT/CT with other imaging modalities and a comparative analysis, where available.

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Hybrid Imaging Worldwide—Challenges and Opportunities for the Developing World: A Report of a Technical Meeting Organized by IAEA

Cited by 19 publications

References 34 publications

Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging

Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging

Current Practices in Myocardial Perfusion Scintigraphy in Brazil and Adherence to the IAEA Recommendations: Results of a Cross-Sectional Study

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

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