2021
DOI: 10.1039/d0tb02454f
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Hybrid magneto-luminescent iron oxide nanocubes functionalized with europium complexes: synthesis, hemolytic properties and protein corona formation

Abstract: The use of hybrid nanostructures based on magneto-luminescent properties is a promising strategy for nano-bio applications and theranostics platforms . In this work, we carried out the synthesis and functionalization...

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Cited by 8 publications
(4 citation statements)
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“…Avoiding agglomeration effects is also of utmost importance when using organic luminophores because the self-aggregation-mediated quenching can largely restrict the luminophores’ practical application. , In addition, the close proximity between luminophores and iron oxide cores leads to a strong emission quenching due to the large UV–vis absorption and scattering of Fe 3 O 4 NPs, and these aggregation effects become more critical as the size of the MNPs increases . Since organic dyes are more sensitive to aggregation and scattering effects, they have started to be replaced by quantum dots and lanthanide complexes in the fabrication of fluorescent nanocomposites, , but at the expense of major toxicity. Therefore, the incorporation of magnetic and optical moieties into a common nanosystem that holds out high biocompatibility, optimal hyperthermia performance, and efficient photoluminescence remains a challenge.…”
Section: Introductionmentioning
confidence: 99%
“…Avoiding agglomeration effects is also of utmost importance when using organic luminophores because the self-aggregation-mediated quenching can largely restrict the luminophores’ practical application. , In addition, the close proximity between luminophores and iron oxide cores leads to a strong emission quenching due to the large UV–vis absorption and scattering of Fe 3 O 4 NPs, and these aggregation effects become more critical as the size of the MNPs increases . Since organic dyes are more sensitive to aggregation and scattering effects, they have started to be replaced by quantum dots and lanthanide complexes in the fabrication of fluorescent nanocomposites, , but at the expense of major toxicity. Therefore, the incorporation of magnetic and optical moieties into a common nanosystem that holds out high biocompatibility, optimal hyperthermia performance, and efficient photoluminescence remains a challenge.…”
Section: Introductionmentioning
confidence: 99%
“…Nanomaterials have developed rapidly in the past decades and applied widely in medical fields due to their excellent biocompatibility and nanoenzyme and drug delivery ability. MnO 2 has recently attracted huge attention as a unique tumor microenvironment-responsive therapeutic drug. MnO 2 could be H + or glutathione (GSH) responsive or generate Mn 2+ ions in the tumor microenvironment, which enhanced the contrast of T 1 magnetic resonance (MR) imaging tumor-specific imaging and detection obviously. At the same time, MnO 2 can trigger the decomposition of hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment, alleviating the tumor hypoxia and oxidative stresses, which is beneficial for reducing drug resistance. Besides, MnO 2 has no long-term toxicity to different tissues because it is excreted by the kidneys quickly. However, there are still few reports on the relationship between the scavenge ROS ability of MnO 2 towards OA.…”
Section: Introductionmentioning
confidence: 99%
“…devido às suas propriedades únicas que diferem dos materiais bulk e as suas elevadas potencialidades para serem utilizadas no desenvolvimento de novas tecnologias. No regime nanométrico, as propriedades magnéticas, ópticas, catalíticas e de transporte de cargas energéticas dos materiais dependem fortemente da sua morfologia, isto é, do tamanho e forma devido à elevada relação superfície/volume e as propriedades eletrônicas únicas(COSTA et al, 2021;ZANCHET, 2017;KHAN et al, 2018;LIMA et al, 2020;TANCREDI et al, 2019).Enquanto os efeitos de tamanho foram intensivamente estudados nas últimas décadas(TANCREDI et al, 2019), a dependência com a forma passou a ser explorada apenas recentemente, devido à dificuldade intrínseca de produzir nanoestruturas com formas bem definidas e em grandes quantidades. No entanto, nos últimos anos, o aprimoramento de métodos de produção, em especial a síntese coloidal de NPs, propiciou a produção de amostras de alta qualidade, motivando o estudo experimental sistemático dos efeitos de forma e o desenvolvimento de novas aplicações (RODRIGUES; DA SILVA; CAMARGO, 2019).…”
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