Hybrid material for open abdomen: saving the wound from intestinal fistula

Zhao, Cheng; Wu, Xiuwen; Huang, Jinjian; Chen, Canwen; Yu, Jiafei; Fang, Miao; Wang, Gefei; Ren, Jianan

doi:10.1007/s10856-019-6311-1

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Injectable hydrogels, similar to the extracellular matrix, can bind isolated tissues and also act as a hemostat or sealant to stop bleeding and prevent fluid or gas leakage and protect against infection, which accelerates wound healing. 70 After controlling the infection, controlling inflammation and cell proliferation is critical to wound healing. The human skin has a natural internal “battery”, which generates a small electrical current during injury, and wound healing stops when the current is disrupted.…”

Section: Biological Properties and Wound Dressing Applications Of Car...mentioning

confidence: 99%

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

et al. 2022

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Section: Biological Properties and Wound Dressing Applications Of Car...mentioning

confidence: 99%

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

et al. 2022

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Establishment and evaluation of an improved rat model of open abdomen

Liu,

Li,

Huang

et al. 2023

Anim Models and Exp Med

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IntroductionThis study aimed to establish an animal model of open abdomen (OA) through temporary abdominal closure via different techniques.MethodsAdult male Sprague–Dawley rats were randomly divided into three groups: group A (OA with polypropylene mesh alone); group B (OA with polypropylene mesh combined with a patch); and group C (OA with polypropylene mesh and a sutured patch). Vital signs, pathophysiological changes, and survival rates were closely monitored in the rats for 7 days after surgery. Abdominal X‐rays and histopathological examinations were performed to assess abdominal organ changes and wound healing.ResultsThe results showed no significant difference in mortality rates among the three groups (p > 0.05). However, rats in group B exhibited superior overall condition, cleaner wounds, and a higher rate of wound healing compared to the other groups (p < 0.05). Abdominal X‐rays indicated that varying degrees of distal intestinal obstruction in all groups. Histopathological examinations revealed fibrous hyperplasia, inflammatory cell infiltration, neovascularization, and collagen deposition in all groups. Group B demonstrated enhanced granulation tissue generation, neovascularization, and collagen deposition compared to the other groups (p < 0.05).ConclusionsPolypropylene mesh combined with patches is the most suitable method for establishing an animal model of OA. This model successfully replicated the pathological and physiological changes in postoperative patients with OA, specifically the progress of abdominal skin wound healing. It provides a practical and reliable animal model for OA research.

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Faecal Microbiota Microsphere Contributed to Relieving Gut Barrier Damage in Colitis

Zhen

Zhao

et al. 2020

Macromol. Res.

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Hybrid material for open abdomen: saving the wound from intestinal fistula

Cited by 4 publications

References 38 publications

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

Establishment and evaluation of an improved rat model of open abdomen

Faecal Microbiota Microsphere Contributed to Relieving Gut Barrier Damage in Colitis

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