Hybrid Materials: Flexible Modulation of CO‐Release Using Various Nuclearity of Metal Carbonyl Clusters on Graphene Oxide for Stroke Remediation (Adv. Healthcare Mater. 5/2018)

Tan, Mein Jin; Pan, Han-Chi; Tan, Hui Ru; Chai, J. W.; Lim, Qi Feng; Wong, Ten It; Zhou, Xiaodong; Hong, Zi-Yao; Liao, Lun-De; Kong, Kien Voon

doi:10.1002/adhm.201870022

Cited by 5 publications

(7 citation statements)

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“…To circumvent these drawbacks and increase targeted and controlled accumulation of CO in the tumor lesions, CORMs have been integrated into diverse endo/exogenous stimuli-responsive nanoscaffolds via noncovalent or covalent bonds interactions . The nanoscaffolds currently used for CO delivery mainly include dendrimers, polymer nanoparticles, , self-assembled peptide and protein supermolecules, − MOFs, silica nanoparticles, UCNPs, magnetic nanoparticles, , and carbon-based nanomaterials. , …”

Section: Gas Releasing Systemsmentioning

confidence: 99%

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Gas-Mediated Cancer Bioimaging and Therapy

et al. 2019

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Gas-involving cancer theranostics have attracted considerable attention in recent years due to their high therapeutic efficacy and biosafety. We have reviewed the recent significant advances in the development of stimuliresponsive gas releasing molecules (GRMs) and gas nanogenerators for cancer bioimaging, targeted and controlled gas therapy, and gas-sensitized synergistic therapy. We have focused on gases with known anticancer effects, such as oxygen (O 2 ), carbon monoxide (CO), nitric oxide (NO), hydrogen sulfide (H 2 S), hydrogen (H 2 ), sulfur dioxide (SO 2 ), carbon dioxide (CO 2 ), and heavy gases that act via the gas-generating process. The GRMs and gas nanogenerators for each gas have been described in terms of the stimulation method, followed by their applications in ultrasound and multimodal imaging, and finally their primary and synergistic actions with other cancer therapeutic modalities. The current challenges and future possibilities of gas therapy and imaging vis-a-vis clinical translation have also been discussed.

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Section: Gas Releasing Systemsmentioning

confidence: 99%

Section: Gas Releasing Systemsmentioning

confidence: 99%

Gas-Mediated Cancer Bioimaging and Therapy

et al. 2019

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“…Kong et al developed a CO‐releasing platform based on the side‐dependent absorption property of ruthenium carbonyl clusters (Ru–CO) onto the surface of graphene oxide (GO), which was further used for the treatment of stroke‐related vascular disease . Ru–CO was conjugated onto the surface of GO with various nuclearities where CO was released via photothermal nanomodulators to form CO‐releasing active species Ru II (CO) 2 by the fragmentation and oxidation of Ru–CO clusters ( Figure a).…”

Section: Carbon Monoxide (Co)‐generating Ggnsmentioning

confidence: 99%

“…Ru–CO was conjugated onto the surface of GO with various nuclearities where CO was released via photothermal nanomodulators to form CO‐releasing active species Ru II (CO) 2 by the fragmentation and oxidation of Ru–CO clusters ( Figure a). These Ru–CO–GO nanocomposites were further evaluated on the effectiveness on the ischemia protection where Raman microscopy clearly showed the high protection effect of Ru–CO–GO hybrid composite as compared to GO because of the CO release (Figure b) . In addition, ruthenium tricarbonyl was integrated with a peptide amphiphile, which was further embedded into self‐assembled nanofiber gels for spontaneously releasing CO with prolonged release kinetics.…”

Section: Carbon Monoxide (Co)‐generating Ggnsmentioning

confidence: 99%

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Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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Tumor Microenvironment‐“AND” Near‐Infrared Light‐Activated Coordination Polymer Nanoprodrug for On‐Demand CO‐Sensitized Synergistic Cancer Therapy

Sun

Jia

Hai

et al. 2020

Adv Healthcare Materials

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Carbon monoxide (CO) as an emerging treatment holds great promise for inducing the apoptosis of cancer cells. Here coordination assembled strategy is first reported for synthesis of Cu(II)‐flavone coordination polymer (NCu‐FleCP) CO nanoprodrug that is stable in normal physiological conditions, and yet readily reduces to small size prodrug complex and releases CO on demand under glutathione (GSH) and near infrared (NIR) light. Specifically, after uptaking by cancer cells, local GSH attacked coordination bond within NCu‐FleCP, resulting in the release of Cu(I) and free Fle. The CC bond of Fle is cleavage under NIR light to release CO for gas therapy, and Cu(I) reacts with local H2O2 through Fenton like reaction to generate hydroxyl radicals (•OH) for chemodynamic therapy. Detailed in vitro and in vivo experiments demonstrate that the CO prodrug system in generating a sufficient quantity of CO and •OH offers remarkable destructive effects against cancer cells without causing toxicity to surrounding normal tissues. The study provides a solid foundation to develop smart coordination polymer CO prodrugs with on‐demand CO release, enhanced permeability and retention effect, and biodegradability for multimodal synergistic therapy.

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Hybrid Materials: Flexible Modulation of CO‐Release Using Various Nuclearity of Metal Carbonyl Clusters on Graphene Oxide for Stroke Remediation (Adv. Healthcare Mater. 5/2018)

Cited by 5 publications

References 0 publications

Gas-Mediated Cancer Bioimaging and Therapy

Gas-Mediated Cancer Bioimaging and Therapy

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Tumor Microenvironment‐“AND” Near‐Infrared Light‐Activated Coordination Polymer Nanoprodrug for On‐Demand CO‐Sensitized Synergistic Cancer Therapy

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