Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures with Improved Degradability by Hydroxyapatite

Hao, Xiaohong; Hu, Xuhua; Zhang, Cuimiao; Chen, Shizhu; Li, Zhenhua; Yang, Xinjian; Liu, Huifang; Jia, Guang; Liu, Dandan; Ge, Kun; Liang, Xing‐Jie; Zhang, Jinchao

doi:10.1021/nn507485j

Cited by 203 publications

(130 citation statements)

References 49 publications

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“…Studies have shown that the degradation of mesoporous materials was faster than non-mesoporous materials, and the degradability of the ordered mesoporous materials was of great significance for their applications in biomedical materials. [31][32][33] Thus, this study further demonstrated that m-MS played a dominant role in the degradation of the composites because of the ordered pore structure, high specific surface area and high pore volume of m-MS. Fig. 5b exhibits the pH value changes of the solution after the samples were soaked in Tris-HCl for different times.…”

Section: Degradability Of M-ms/wp Compositessupporting

confidence: 58%

Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

Feng

Jiang

et al. 2016

J. Mater. Chem. B

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A novel bioactive composite based on wheat protein (WP) and mesoporous magnesium silicate (m-MS) with a high specific surface area is presented in this study for potential bone tissue regeneration. Wheat protein (WP) is a type of a biodegradable natural polymer material. The m-MS was prepared by the sol-gel technique, which was incorporated into WP to fabricate m-MS/WP composites. The increasing amount of m-MS improved the surface hydrophilicity of m-MS/WP composites. The results showed that the degradation ratio of the m-MS/WP composites increased with an increase in the m-MS content after it was soaked in a Tris-HCl solution for 12 weeks. Moreover, the m-MS/WP composites with 40 wt% m-MS content (WP40) were able to maintain a suitable pH value over a prolonged soaking time, which might be dependent on the content of the m-MS. The WP40 showed a good apatite formation ability after it was soaked in simulated body fluid (SBF) for 7 days, indicating good bioactivity. Moreover, the WP40 with cytocompatibility stimulated the attachment, proliferation and differentiation of MC3T3-E1 osteoblast cells. Briefly, the results indicated that WP40 had good bioactivity, degradability, cytocompatibility and osteogenesis and might be a new biomaterial for bone regeneration.

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Section: Degradability Of M-ms/wp Compositessupporting

confidence: 58%

Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

Feng

Jiang

et al. 2016

J. Mater. Chem. B

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“…This further confirmed that TP had been successfully embedded in the cavities of SCP nanospheres. Overall, the total loading capacity of TP in SCP was determined to be 45.6 wt.%, much larger than that in porous silica nanospheres [25] and mesoporous BG nanoparticles [13]. Fig.…”

Section: Resultsmentioning

confidence: 85%

Bioactive SiO2-CaO-P2O5 hollow nanospheres for drug delivery

Luo

Wang

et al. 2016

Journal of Non-Crystalline Solids

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“…16 In particular, biomaterials that exist abundantly in the body are good candidates for constructing biodegradable nanomaterials. Among various biomaterials, DNA has been used as a programmable building block for the assembly of different nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy

Jin

Liu

et al. 2017

NPG Asia Mater

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Safety and efficiency remain the critical hurdles hindering the practical application of gene agents, even though great effort has been made to develop various gene carriers. Herein, we present a novel biodegradable cancer therapeutic system based on DNA nanoflowers (DNFs) for targeted dual gene silencing. The therapeutic system was constructed by copying a rolling circle amplification template to produce long single-stranded DNAs with cell targeting and dual gene-silencing capability. The structure of the DNFs collapsed at acidic pH due to the decomposition of the co-assembled magnesium pyrophosphate, generating Mg 2+ ions that act as cofactors for the DNAzymes and increase their ability to recognize and cleave target mRNAs. In vitro and in vivo studies demonstrated that the multifunctional DNFs showed promise for targeted cancer cell recognition, gene silencing, induction of apoptosis and inhibition of tumor growth. Considering the enhanced therapeutic effect and biocompatibility of this therapeutic platform, it is anticipated to be of great interest for the clinical treatment of cancers.

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Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures with Improved Degradability by Hydroxyapatite

Cited by 203 publications

References 49 publications

Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite

Bioactive SiO2-CaO-P2O5 hollow nanospheres for drug delivery

Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy

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