Hybrid monolithic columns coated with cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparations in capillary electrochromatography and capillary liquid chromatography

Photografted methacrylate‐based monolithic columns coated with cellulose tris(3,5‐dimethylphenylcarbamate) for chiral separation in CEC

“…Our results were better than those reported by He et al [2] using monolithic silica capillary with immobilized CDMPC through an intermolecular polycondensation or radical copolymerization (resolution value < 0.5 for Tröger's base). Our resolution values were comparable with other works reported for silica (resolution values ranged 1.7-3.9) [42,43] or polyacrylamide-based (resolution values between 1.47 and 2.70) [9] monoliths coated with CDMPC under similar mobile phase conditions. In any case, it should be remarked that the developed CSP provided an incipient separation of basic compounds such as propranolol and mefloquin.…”

“…The results showed that retention factor and resolution decreased with increasing ACN content in mobile phase from 30 to 40%. This trend suggested a hydrophobic interaction, typical in reversed‐phase separations, between the CDMPC selector and chiral analytes . As it can be seen, the best compromise between enantioseparation and analysis time was achieved with 35% ACN in the mobile phase, and it was selected for further experiments.…”

Facile preparation of a stable and functionalizable hybrid monolith via ring-opening polymerization for capillary liquid chromatography

“…As a low cost, rapid, effective, reproducible as well as high flexible separation technique, cLC has become a perfect tool for chiral separation [36,[39][40][41][42]. Owing to the high column efficiency and mechanical stability, the raw POSS-PEI hybrid monolith was physically coated with CDMPC for chiral separation (as shown in Fig.…”

“…The preparation of CDMPC-coated hybrid monolithic column was performed according to the approach presented in previous reports [35,36]. In brief, a POSS-PEI hybrid monolithic column was flushed with acetone at about 3 MPa, then the column was connected to a stainless-steel HPLC column (50 × 4 mm i.d.…”

Advances in monolithic silica columns for high-performance liquid chromatography

“…). Ou et al prepared hybrid monolithic capillary column synthesized by using (3-chloropropyl)-trimethoxysilane and TMOS by using sol-gel chemistry for enantioseparations in capillary electrochromatography and capillary liquid chromatography (CLC) (Ou et al 2012). Wang et al prepared a hybrid-silica monolithic column for the analysis of nucleotides by capillary electrochromatography.…”