Hybrid nano-architectures loaded with metal complexes for the co-chemotherapy of head and neck carcinomas

Abstract

Head and neck squamous cell carcinoma (HNSCC) are a complex group of malignancies that affect different body sites pertaining to the oral cavity, pharynx and larynx. Their treatment relies on...

Drug-Free Hybrid Nanoarchitecture Modulation of the Metastatic Behavior of Pancreatic Ductal Adenocarcinoma in Alternative in Vivo Models

“…38 The synthetic protocol is standardized with a high batch-by-batch homogeneity, and its versatility is demonstrated by the possibility to include various metals (gold, silver, platinum, copper) and/or active molecules or dyes. 39,40 As we have already demonstrated, plasmon USMNPs enclosed in NAs are efficiently excreted after intravenous injection or intranasal instillation in healthy mice. 15−17 The hydrodynamic diameter and zeta potential of NAs were measured using Dynamic Light Scattering (DLS), whereas the size was assessed through Transmission Electron Microscopy (TEM) imaging (Figure 1b,c), and the metal content was determined using Inductively Coupled Plasma− Mass Spectrometry (ICP−MS) (Table 2).…”

“…The polymeric templates enclosing USMNPs are embedded in a silica capsule formed via a modified Stöber reaction (final diameter: ∼150 nm). , The silica shell protects the inner core and provides a modifiable surface for active targeting purposes . The synthetic protocol is standardized with a high batch-by-batch homogeneity, and its versatility is demonstrated by the possibility to include various metals (gold, silver, platinum, copper) and/or active molecules or dyes. , As we have already demonstrated, plasmon USMNPs enclosed in NAs are efficiently excreted after intravenous injection or intranasal instillation in healthy mice. − The hydrodynamic diameter and zeta potential of NAs were measured using Dynamic Light Scattering (DLS), whereas the size was assessed through Transmission Electron Microscopy (TEM) imaging (Figure b,c), and the metal content was determined using Inductively Coupled Plasma–Mass Spectrometry (ICP–MS) (Table ). The similar morphological features of AuNAs and CuNAs allow to correlate the biological effects to the chemical nature of the inner metal …”

Copper nano-architecture topical cream for the accelerated recovery of burnt skin

“…24,26,27 NAs enclosing gold have been primarily developed for the non-invasive treatment of oral carcinoma. 28,51 Herein, we present rationally designed copper-containing nano-architectures (CuNAs) as an active agent of a homemade cosmetic cream for the effective treatment of burnt skin. The rational design of biodegradable NAs allows for good skin penetration together with long-term action.…”

“…24,26,27 NAs enclosing gold have been primarily developed for the non-invasive treatment of oral carcinoma. 28,51…”

Hyperthermia Reduces Irradiation‐Induced Tumor Repopulation in an In Vivo Pancreatic Carcinoma Model

“…The evaluations have been performed on optimized pancreatic carcinoma chick embryo chorioallantoic membrane (CAM) models, an in vivo system that provides a suitable environment to support tumor growth in agreement to the European Parliament Directive 2010/63/EU 14 . The employment of the CAM tumor model finds increasing importance for the investigation of various therapeutic strategies in oncological research 13,38,39 . The direct monitoring of tumor growth provides rapid assessment of potential tumor‐reducing effect and morphological alteration following the treatment.…”