Hybrid nanoparticles for the topical delivery of norfloxacin for the effective treatment of bacterial infection produced after burn

Dave, Vivek; Kushwaha, Kriti; Yadav, Reena; Agrawal, Udita

doi:10.1080/02652048.2017.1337249

Cited by 25 publications

(7 citation statements)

References 21 publications

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“…Reports have focused on the encapsulation of antimicrobials into polymeric nanoparticles [224,225]. For instance, LL37-loaded PLGA nanoparticles accelerated wound healing, exhibited antibacterial activity against E. coli, and induced cell migration without affecting the proliferation and metabolism of keratinocytes in HaCaT cells.…”

Section: Antibiotic-loaded Nanoparticles (Nanobiotics)mentioning

confidence: 99%

“…Norfloxacin-loaded nanoparticles also had better performance against S. aureus and P. aeruginosa., bringing hope to the treatment of burn-induced infections [225]. The gelatin microencapsulation of FGF-2 preserved its biological activity, promoting its application in therapeutic angiogenesis, gene therapy, tissue engineering, and drug delivery (Table 4) [226].…”

Section: Antibiotic-loaded Nanoparticles (Nanobiotics)mentioning

confidence: 99%

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Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

2022

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Nanoparticles are the gateway to the new era in drug delivery of biocompatible agents. Several products have emerged from nanomaterials in quest of developing practical wound healing dressings that are nonantigenic, antishear stress, and gas-exchange permeable. Numerous studies have isolated and characterised various wound healing nanomaterials and nanoproducts. The electrospinning of natural and synthetic materials produces fine products that can be mixed with other wound healing medications and herbs. Various produced nanomaterials are highly influential in wound healing experimental models and can be used commercially as well. This article reviewed the current state-of-the-art and briefly specified the future concerns regarding the different systems of nanomaterials in wound healing (i.e., inorganic nanomaterials, organic and hybrid nanomaterials, and nanofibers). This review may be a comprehensive guidance to help health care professionals identify the proper wound healing materials to avoid the usual wound complications.

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Section: Antibiotic-loaded Nanoparticles (Nanobiotics)mentioning

confidence: 99%

Section: Antibiotic-loaded Nanoparticles (Nanobiotics)mentioning

confidence: 99%

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

2022

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“…A lipid polymer hybrid NP was developed for sustained drug (norfloxacin) release up to 24 h, having potential in treating burn induced infections. These NPs loaded with norfloxacin also performed well in antimicrobial efficacy tests against P. aeruginosa and S. aureus . Also, fibrin has been widely used for wound healing and tissue engineering applications as it increases the immunological response and cell adhesion properties and reduces inflammation .…”

Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 89%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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“…20 μl of the Flurbiprofen loaded ethosomal suspension was diluted with millipore water and was allowed to stain with 2% w/v phosphotungstic acid for about 30 s. Sample was placed on coated copper grid and was allowed to dry. For every sample, two grids were prepared and randomly viewed [7].…”

Section: Methodsmentioning

confidence: 99%

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

et al. 2019

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Background Ethosomes have been widely used in Transdermal Drug Delivery System (TDDS) as they increase the permeation of drug across the skin. Methods Flurbiprofen loaded vesicular ethosomes were formulated, optimized and characterized for particle size, entrapment efficiency, poly dispersive index (PDI), microscopy using Atomic force microscopy (AFM), Scanning electron microscope (SEM) and Transmission electron microscopy (TEM) and Interaction of drug and excipients were studied using Fourier transform infra-red (FTIR) spectroscopy, Differential scanning colorimetry (DSC), Thermo gravimetric analysis (TGA). Further, ethosomal formulations of flurbiprofen were evaluated for stability study of three months and in vitro drug permeation study was carried out using albino rat skin. In addition, skin irritation test was evaluated by Draize test and in vivo study of prepared formulation was examined through paw edema assay by inducing carrageenan and cold plate method. Results Amongst all formulations, EF5 formulation exhibited ideal surface morphology, with maximum entrapment efficiency (95%) with optimal excipient concentration i.e. 200 mg phospholipid and 35% ethanol. The ideal vesicle size was achieved as 162.2 ± 2 nm, with zeta potential − 48.14 ± 1.4 mV with the PDI of 0.341. In-vitro permeation study shows a release of 82.56 ± 2.11 g/cm 2 in 24 h and transdermal flux was found as 226.1 μg/cm 2 /h. Cold plate test indicates that the formulation EF5 showed a marked analgesic activity and Carrageenan induced paw edema test indicates that the formulation EF5 inhibits the increase in paw edema. Ethosomal suspension at 4 °C showed maximum stability. Conclusions The overall study concluded that this ethosomal approach offers a new delivery system for sustained and targeted delivery for flurbiprofen. Electronic supplementary material The online version of this article (10.1186/s12944-019-1064-x) contains supplementary material, which is available to authorized users.

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Hybrid nanoparticles for the topical delivery of norfloxacin for the effective treatment of bacterial infection produced after burn

Cited by 25 publications

References 21 publications

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

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