The Internet of Things (IoT) combines various sensors and the internet to form an expanded network, realizing the interconnection between human beings and machines anytime and anywhere. Nevertheless, the problem of energy supply limits the large-scale implementation of the IoT. Fortunately, thermoelectric generators (TEGs), which can directly convert thermal gradients into electricity, have attracted extensive attention in the IoT field due to their unique benefits, such as small sizes, long maintenance cycles, high stability, and no noise. Therefore, it is vital to integrate the significantly advanced research on TEGs into IoT. In this review, we first outline the basic principle of the thermoelectricity effect and summarize the common preparation methods for thermoelectric functional parts in TEGs. Then, we elaborate on the application of TEG-powered sensors in the human body, including wearable and implantable medical electronic devices. This is followed by a discussion on the application of scene sensors for IoTs, for example, building energy management and airliners. Finally, we provide a further outlook on the current challenges and opportunities.