(Hybrid) SPECT and PET Technologies

Nolte, Teresa; Groß‐Weege, Nicolas; Schulz, Volkmar

doi:10.1007/978-3-030-42618-7_3

Cited by 13 publications

(8 citation statements)

References 74 publications

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“…For theranostics, radionuclides should have characteristics for therapeutic and diagnostic purposes. The ideal radionuclide used in these scenarios is one that generates α, ß-, or Auger electrons for treatment and ß+, or γ radiations for imaging, with the γ radiation optimally around 140 keV so that they can be detected by cameras with minimal background (Nolte et al 2020 ). Accordingly, this is accomplished using a single radionuclide or a combination of radionuclides or a theranostic pair where the diagnostic agent is radiolabeled with an imaging radionuclide and the therapeutic agent is radiolabeled with a physiochemically matched radionuclide.…”

Section: Types Of Radionuclidesmentioning

confidence: 99%

Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

2023

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In the last three decades, radiopharmaceuticals have proven their effectiveness for cancer diagnosis and therapy. In parallel, the advances in nanotechnology have fueled a plethora of applications in biology and medicine. A convergence of these disciplines has emerged more recently with the advent of nanotechnology-aided radiopharmaceuticals. Capitalizing on the unique physical and functional properties of nanoparticles, radiolabeled nanomaterials or nano-radiopharmaceuticals have the potential to enhance imaging and therapy of human diseases. This article provides an overview of various radionuclides used in diagnostic, therapeutic, and theranostic applications, radionuclide production through different techniques, conventional radionuclide delivery systems, and advancements in the delivery systems for nanomaterials. The review also provides insights into fundamental concepts necessary to improve currently available radionuclide agents and formulate new nano-radiopharmaceuticals.

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Section: Types Of Radionuclidesmentioning

confidence: 99%

Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

2023

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“…The nuclear cameras rotate around the patient, while gamma photons radiating from the patient's body pass through the collimator and finally hit the detector plane. After the detectors collect all the data (the location of the interaction and photon energy), they can create an image of the tissues [176]. The spatial resolution depends mainly on the type of collimator used, as it can improve with a collimator with smaller and longer holes.…”

Section: Single-photon Emission Computed Tomographymentioning

confidence: 99%

“…Radiotracers used in SPECT include 99m Tc, 201 Tl, 67 Ga, or 123 I. They all have a long half-life time that varies between several hours and days, allowing a long imaging time and making the diagnostic accuracy highly time-dependent [176].…”

Section: Single-photon Emission Computed Tomographymentioning

confidence: 99%

Imaging of Uveal Melanoma—Current Standard and Methods in Development

Solnik

Paduszyńska

Czarnecka

et al. 2022

Cancers

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Uveal melanoma is the most common primary intraocular malignancy in adults, characterized by an insidious onset and poor prognosis strongly associated with tumor size and the presence of distant metastases, most commonly in the liver. Contrary to most tumor identification, a biopsy followed by a pathological exam is used only in certain cases. Therefore, an early and noninvasive diagnosis is essential to enhance patients’ chances for early treatment. We reviewed imaging modalities currently used in the diagnostics of uveal melanoma, including fundus imaging, ultrasonography (US), optical coherence tomography (OCT), single-photon emission computed tomography (SPECT), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), fundus autofluorescence (FAF), as well as positron emission tomography/computed tomography (PET/CT) or magnetic resonance imaging (MRI). The principle of imaging techniques is briefly explained, along with their role in the diagnostic process and a summary of their advantages and limitations. Further, the experimental data and the advancements in imaging modalities are explained. We describe UM imaging innovations, show their current usage and development, and explain the possibilities of utilizing such modalities to diagnose uveal melanoma in the future.

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“…The nuclear cameras rotate around the patient while gamma photons radiating from the patient body pass through the collimator and finally hit the detector plane. After detectors collect all the data (location of the interaction, photon energy), they can create an image of the tissues [158]. Spatial resolution is dependent mainly on the type of used collimator as it can improve with the use of a collimator with smaller and longer holes.…”

Section: Single-photon Emission Computed Tomographymentioning

confidence: 99%

“…Radiotracers used in SPECT include 99m Tc, 201 Tl, 67 Ga, or 123 I. All of them have a long half-life time that varies between several hours and days, allowing a long imaging time and making the diagnostic accuracy highly time-dependent [158].…”

Section: Single-photon Emission Computed Tomographymentioning

confidence: 99%

New Perspectives in Imaging of Uveal Melanoma

Solnik¹,

Paduszynska²,

Czarnecka³

et al. 2021

Preprint

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Uveal melanoma is the most common primary intraocular malignancy in adults characterized by insidious onset and poor prognosis strongly associated with tumor size and the presence of distant metastases, most commonly in the liver. Contrary to most tumor identification, biopsy followed by pathological exam is not recommended in ophthalmic oncology. Therefore, early and non-invasive diagnosis is essential to enhance patients’ chances for early treatment possibilities. We reviewed imaging modalities currently used in the diagnosis of uveal melanoma, i.e., fundus imaging, ultrasonography (US), optical coherence tomography (OCT), single-photon emission computed tomography (SPECT), positron emission tomography/computed tomography (PET/CT), magnetic resonance imaging (MRI), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), fundus autofluorescence (FAF). The principle of imaging techniques was briefly explained, along with their role in the diagnostic process and a summary of their advantages and limitations. Further, the experimental data and the advancements in imaging modalities were searched. We described their innovations, showed current usage and research, and explained the possibilities of utilizing them to diagnose uveal melanoma and their potential application in personalized medicine such as theranostics.

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(Hybrid) SPECT and PET Technologies

Cited by 13 publications

References 74 publications

Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

Imaging of Uveal Melanoma—Current Standard and Methods in Development

New Perspectives in Imaging of Uveal Melanoma

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