Hydrazone analogues with promising antibacterial profiles: Synthesis, morphology, in vitro and in silico approaches

Abstract

Significance and Impact of the Study: Bacterial resistance development against commercial antibiotics has become one of the most significant global problems. There is a strong demand for the discovery of novel classes of antibiotics with high efficiency, low dose, no toxicity and affordable cost. According to the results described in this research, non-toxic nitrobenzylidene(quinazolin-4-yl)hydrazines (compounds 1b and 2b) can be considered promising medications for the treatment of infectious diseases owing to their proper activity against various susceptible and resistant bacteria. Furthermore, they can become industrialized because of their convenient and high-yield synthesis.

Tetrahydroisoquinoline based 5-nitro-2-furoic acid derivatives: a promising new approach for anti-tubercular agents

“…14,15 These NF derivatives containing typical hydrazide/hydrazone moieties may affect other infectious diseases, especially leishmaniasis, trypanosomiasis, tuberculosis, and cancer. [16][17][18][19][20][21] Several nitrofuran compounds with anti-tubercular activity have been reported. [19][20][21] Fig.…”

Synthesis and Antibacterial Activity of Some Aryloxyacetic Acid Derivatives Containing Aryl Sulfonate Moiety

“…In recent years, much attention has been devoted to the synthesis of new hydrazones and to testing these molecules for antibacterial activity. [2][3][4][5] In this direction, Nabizadeh et al 6 reported nitro benzylidene (quinazoline-4-yl) hydrazine scaffold as an antimicrobial agent. Balasubramaniyan et al 7 reported the synthesis of 2r,6c-diaryl-3t-methylpiperidin-4-one arylsulphonylhydrazones and showed that they exhibit significant activity against bacteria.…”