Hydro-Methanolic Extract of Cornus Mas L. and Blood Glucose, Lipid Profile and Hematological Parameters of Male Rats

Abstract

Background:Cornus mas L, an olive-shaped red-colored single-seeded fruit, is used in traditional medicine in different parts of Europe and Asia.Objectives:In the present study, 40 male Wistar rats were randomly divided into five groups, and the effects of 21 days of intraperitoneally (IP) administration of 50, 200 and 400 mg/kg body weight of C. mas hydro-methanolic extract on the rats hematological and biochemical parameters were investigated. The experimental study was carried out in Tabriz, Iran.Materials and Methods:The hematology and biochemical tests were performed by the Technicon H1 Hematology Analyzer and enzymatic methods, respectively.Results:The results indicated that all doses of the extract caused significant (P < 0.05) decreases in the hemoglobin distribution width (HDW) (2.3 ± 0.2 vs. 2.5 ± 0.2, P = 0.049) and platelet distribution width (PDW) (56.5 ± 1.8 vs. 63.9 ± 3.6, P = 0.001) of the treated groups vs. control group, whereas only high doses caused significant elevation in the mean corpuscular hemoglobin concentration (MCHC) (30.3 ± 0.8 vs. 28.6 ± 0.6, P = 0.047), mean platelet volume (MPV) (5.0 ± 0.6 vs. 4.1 ± 0.3, P = 0.002), total platelet mass (PCT) (0.33 ± 0.07 vs. 0.26 ± 0.01, P = 0.050), and significant decrease in the red cell distribution width (RDW) (13.8 ± 0.4 vs. 14.7 ± 1.3, P = 0.048) of the treated groups vs. control group.Conclusions:Decreasing effect of the extract on platelet activity might classify it as an alternative for antiplatelet therapy in cardiovascular diseases (CVD). The results of this study suggested that further investigations with higher doses of C. mas fruit extract are necessary to obtain significant protective and nonprotective changes in hematological and biochemical parameters.

The effect of Cornus mas fruit extract consumption on lipid profile, glycemic indices, and leptin in postmenopausal women— A randomized clinical trial

“…In many studies, Cornus mas have not been effective in altering lipid profiles (Basu et al, 2011;Chamberlain & Bowen-Simpkins, 2000). Only a slight decrease, but not significant, was observed in cholesterol and HDL-cholesterol, respectively (Abdollahi et al, 2014).…”

“…After 3 weeks of intervention, there was no significant difference in mean serum triglyceride, LDL‐cholesterol, HDL‐cholesterol, and total cholesterol. Only a slight decrease, but not significant, was observed in cholesterol and HDL‐cholesterol, respectively (Abdollahi et al, ). Mirbeldzadeh et al in a study showed that the extract of Cornus mas fruit significantly reduced serum triglyceride and LDL cholesterol levels compared with diabetic control group.…”

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

“…Therefore, inhibiting the production of superoxide anion (·${\text{O}}_2^{-}$) and increasing the biological power of NO consequently regulate glycoprotein pine receptors (GPIIb-IIIa) on platelet membrane surface, that in turn inhibits platelets' activation and their adherence during inflammation and thrombosis processes. Decreasing effect of the fruit extract on platelet activity might classify it as an alternative for antiplatelet therapy in cardiovascular diseases (Abdollahi et al, 2014). Unfortunately, clinical studies investigating this aspect of activity have not been published to date.…”

The Effects of Cornus mas Hydro-Methanolic Extract on Cisplatin-Induced Nephrotoxicity in Rats

“…The CME has considerable vitamin C content. [12][13][14][15][16] In some previous studies, oral administration of vitamin C showed remarkable protection against kidney damage and histopathological changes induced by cisplatin, lead, and nickel in rats. [33][34][35] More investigations are needed to explain the underlying mechanisms of the protective effects that remain unexplained.…”

“…It was also reported to have anti-allergic and anti-microbial activities. 13,17 Cornus mas (C. mas) can be an interesting natural source for decreasing systemic and tissue oxidative stress. 15 This experimental study was designed to investigate cisplatininduced nephrotoxicity in rats and the possible protective effects of C. mas hydro-methanolic fruit extract (CME) against it by using biochemical and histopathological parameters.…”