Hydroalcoholic extract fromAbelmoschus manihot(Linn.) Medicus flower reverses sleep deprivation-evoked learning and memory deficit

Abstract

Extract of Abelmoschus manihot flower (EAM) has the potential to ameliorate learning and memory deficit, in part through inhibiting oxidative stress in the brain.

Inconsistent effects of sleep deprivation on memory function

“…Acute SD induces oxidative stress and subsequent memory impairments (Aleisa et al, 2011[ 2 ]). A previous research has shown that SD impairs object location recognition and passive avoidance memories via increasing oxidative stress in the brain (Zhou et al, 2020[ 129 ]). It has also been revealed that 5-day TSD induces spatial memory decline in the Morris water maze task through increasing oxidative stress in the hippocampus of rats (Wang et al, 2018[ 119 ]).…”