Inconsistent effects of sleep deprivation on memory function

Vaseghi, Salar; Arjmandi-Rad, Shirin; Kholghi, Gita; Nasehi, Mohammad

doi:10.17179/excli2021-3764

Cited by 10 publications

(4 citation statements)

References 127 publications

(206 reference statements)

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“…It is well established that sleep has an influence on memory formation (Foroutannia et al, 2021;Rasch & Born, 2013), though conflicting findings or viewpoints exist for the precise role of sleep in memory (Poe, 2017;Sara, 2017;Vaseghi et al, 2021). In the present study, we used a widely adopted behavioural paradigm, one-trial passive avoidance learning (Ferry & McGaugh, 2008;Garbossa et al, 2022;Garcia-Pardo et al, 2017;Isaacson & Wickelgren, 1962;Sara et al, 1975), to investigate the function of sleep in memory formation.…”

Section: Discussionmentioning

confidence: 99%

Impact of single‐trial avoidance learning on subsequent sleep

Zhang,

Chen

2024

Eur J of Neuroscience

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Both non‐rapid eye movement (NonREM) sleep and rapid eye movement (REM) sleep, as well as sleep spindle and ripple oscillations, are important for memory formation. Through cortical EEG recordings of prefrontal cortex and hippocampus during and after an inhibitory avoidance task, we analysed the dynamic changes in the amounts of sleep, spindle and ripple oscillations related to memory formation. The total amount of NonREM sleep was reduced during the first hour after learning. Moreover, significant decrease of the total spindle and ripple counts was observed at the first hour after learning as well. In addition, foot shock alone, with no associated learning, produced little effect on the dynamics of sleep oscillations, indicating that the learning experience is necessary for these changes to occur.

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Section: Discussionmentioning

confidence: 99%

Impact of single‐trial avoidance learning on subsequent sleep

Zhang,

Chen

2024

Eur J of Neuroscience

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“…There remain many gaps in our understanding of brain development in rodents and humans, despite the fact that these are the species that have been most thoroughly evaluated to date [ 197 ]. While several rodent studies have investigated the impact of SD on memory, results are inconsistent [ 198 ]. Although some studies indicate that SD negatively affects memory, others have found no impairment and even improvements in memory performance [ 128 , 199 ].…”

Section: Potentially Relevant Mechanismsmentioning

confidence: 99%

The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models

et al. 2023

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In this narrative review article, we discuss the role of sleep deprivation (SD) in memory processing in rodent models. Numerous studies have examined the effects of SD on memory, with the majority showing that sleep disorders negatively affect memory. Currently, a consensus has not been established on which damage mechanism is the most appropriate. This critical issue in the neuroscience of sleep remains largely unknown. This review article aims to elucidate the mechanisms that underlie the damaging effects of SD on memory. It also proposes a scientific solution that might explain some findings. We have chosen to summarize literature that is both representative and comprehensive, as well as innovative in its approach. We examined the effects of SD on memory, including synaptic plasticity, neuritis, oxidative stress, and neurotransmitters. Results provide valuable insights into the mechanisms by which SD impairs memory function.

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“…Our purpose here is to provide a framework for better understanding the growing body of evidence on the effects of sleep deprivation before learning. Although there are typically large effects of sleep deprivation on subsequent learning, multiple investigators have noted that there is substantial variation in these effects for reasons that are as yet unknown ( Cousins and Fernández, 2019 ; Vaseghi et al, 2021 ). We believe that lessons from the history of studies of memory impairment from hippocampal lesions, which produce anterograde amnesia, suggest that viewing sleep deprivation as producing a deficit in “encoding capacity” may be misleading and may obscure important connections between memorial effects of sleep loss and other cognitive processes not typically considered in a memory context.…”

Section: Introductionmentioning

confidence: 99%

Temporary amnesia from sleep loss: A framework for understanding consequences of sleep deprivation

2023

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Throughout its modern history, sleep research has been concerned with both the benefits of sleep and the deleterious impact of sleep disruption for cognition, behavior, and performance. When more specifically examining the impact of sleep on memory and learning, however, research has overwhelmingly focused on how sleep following learning facilitates memory, with less attention paid to how lack of sleep prior to learning can disrupt subsequent memory. Although this imbalance in research emphasis is being more frequently addressed by current investigators, there is a need for a more organized approach to examining the effect of sleep deprivation before learning. The present review briefly describes the generally accepted approach to analyzing effects of sleep deprivation on subsequent memory and learning by means of its effects on encoding. Then, we suggest an alternative framework with which to understand sleep loss and memory in terms of temporary amnesia from sleep loss (TASL). The review covers the well-characterized properties of amnesia arising from medial temporal lobe lesions and shows how the pattern of preserved and impaired aspects of memory in amnesia may also be appearing during sleep loss. The view of the TASL framework is that amnesia and the amnesia-like deficits observed during sleep deprivation not only affect memory processes but will also be apparent in cognitive processes that rely on those memory processes, such as decision-making. Adoption of the TASL framework encourages movement away from traditional explanations based on narrowly defined domains of memory functioning, such as encoding, and taking instead a more expansive view of how brain structures that support memory, such as the hippocampus, interact with higher structures, such as the prefrontal cortex, to produce complex cognition and behavioral performance, and how this interaction may be compromised by sleep disruption.

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Inconsistent effects of sleep deprivation on memory function

Cited by 10 publications

References 127 publications

Impact of single‐trial avoidance learning on subsequent sleep

Impact of single‐trial avoidance learning on subsequent sleep

The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models

Temporary amnesia from sleep loss: A framework for understanding consequences of sleep deprivation

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