HYDROCHALCONE COMPOUNDS FROM INDONESIAN MEDICINAL PLANT, “SIRIH HUTAN”, Piper aduncum (Piperaceae)

Abstract

Isolation, purification and identification of two hydrochalcone compounds from Indonesian medicinal plant "Sirihhutan", Piper aduncum (Piperaceae) had been done. Isolation and purification of ethylacetate extract subjected to column chromatography (SiO 2 ; (i).n-hexane-ethylacetate = 10:1 ~ 1 : 1; ethylacetate (ii).n-hexaneethylacetate = 8: 1 gave two pure compounds. Based on infra red, 1D & 2D-NMR, mass spectral data and comparison chemical shift of protons and carbons, the isolated compounds are 2',6'-dihydroxy-4'-methoxy dihydrochalcone and 2',6',4-trihydroxy-4'-methoxy dihydrochalcone with free radical scavenging inhibitionvalues are 21.77 % and 90.1 % respectively.

Etlingera Genus: Phytochemical Screening and Anticancer Activity

“…The chalcone-derived flavonoid compounds also have various activities. Compounds 2',6'dihydroxy-4'-methoxy-dihydrochalcone (36) were reported to have activity as antiplasmodial (Gutierrez et al, 2015;Portet et al, 2007), anticancer (Gutierrez et al, 2015), antioxidant (Gutierrez et al, 2015;Kartika et al, 2019) and antibacterial (Nowakowska, 2007). The compounds 2',4',6'-trihydroxydihydrochalcone (37) have an antimicrobial effect (Gutierrez et al, 2015).…”

“…The compounds 2',4',6'-trihydroxydihydrochalcone (37) have an antimicrobial effect (Gutierrez et al, 2015). Compounds 2 ', 6', 4-trihydroxy-4'-methoxydihydrochalcone (38) are active as anticancer (Gutierrez et al, 2015) and antioxidant (Kartika et al, 2019). Meanwhile, adunctin E (39) and methyllinderatin (40) have been known to be antibacterial (Dethe & Dherange, 2015) and antiplasmodial (Gutierrez et al, 2015;Portet et al, 2007).…”

Etlingera Genus: Phytochemical Screening and Anticancer Activity

“…Antivenom, antidiarrhoeal, trypanocidal, and anti-aromatase (N. K. Patel et al, The chalcone-derived flavonoid compounds also have various activities. Compounds 2',6'-dihydroxy-4'-methoxy-dihydrochalcone (36) were reported to have activity as antiplasmodial (Gutierrez et al, 2015;Portet et al, 2007), anticancer (Gutierrez et al, 2015), antioxidant (Gutierrez et al, 2015;Kartika et al, 2019) and antibacterial (Nowakowska, 2007). The compounds 2',4',6'-trihydroxydihydrochalcone (37) have an antimicrobial effect (Gutierrez et al, 2015).…”