Hydrochloric Acid Infusion for Treatment of Severe Metabolic Alkalosis in a Neonate

The Air‐Bubble Method of Locking Central‐Vein Catheters with Acidified, Concentrated Sodium Chloride as a Bactericidal Agent: In Vitro Studies

“…In regard to the low pH, concentrated hydrochloric acid (HCl) has been used to treat severe metabolic alkalosis [44][45][46][47][48][49], metabolic alkalosis combined with respiratory acidosis [50,51], and severe metabolic alkalosis resulting from citrate dialysis [52]. Most authors used 0.15 m solutions in distilled water (pH 1.5, 300 mOsm/kg).…”

Neonatal alkalemia associated with potential hypovolemia in an infant born to a severely dehydrated mother

“…Metabolic alkalosis results from a loss of body acids, ingestion of bases, or reduction of extracellular volume via fluid loss proportionately higher in chloride than bicarbonate 1–3 . In the early neonatal period, this condition is uncommon; the causes include renal, endocrine, gastrointestinal, metabolic, and maternal disorders, as well as exogenous sources.…”

“…In the early neonatal period, this condition is uncommon; the causes include renal, endocrine, gastrointestinal, metabolic, and maternal disorders, as well as exogenous sources. Neonatal hypochloremia is usually secondary to the use of diuretics 1–3 …”

“…Metabolic alkalosis in the early neonatal period is rare and is most often secondary to hyperemesis or the use of diuretics 1–3 . Maternal electrolyte imbalance is also known to cause neonatal alkalemia 1 .…”