Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

Marik, Paul E.; Khangoora, Vikramjit; Rivera, Racquel; Hooper, Michael H.; Catravas, John D.

doi:10.1016/j.chest.2016.11.036

Cited by 817 publications

(1,011 citation statements)

References 83 publications

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“…Recent evidence suggests that patients with sepsis may have improved outcomes when treated with a conservative, physiologically guided fluid strategy and state-of-the-art supportive care together with a novel pharmacologic intervention [3,4,36,37]. Following this strategy patients with sepsis and septic shock may not develop progressive organ failure, with a reported mortality of less than 10%, this being despite poor compliance with the SEP-1 mandate (only 11%) [37].…”

Section: Options For the Futurementioning

confidence: 99%

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The SEP-1 quality mandate may be harmful: How to drown a patient with 30 mL per kg fluid!

Marik

Malbrain

2017

Anaesthesiol Intensive Ther

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Section: Options For the Futurementioning

confidence: 99%

“…Following this strategy patients with sepsis and septic shock may not develop progressive organ failure, with a reported mortality of less than 10%, this being despite poor compliance with the SEP-1 mandate (only 11%) [37].…”

Section: Options For the Futurementioning

confidence: 99%

The SEP-1 quality mandate may be harmful: How to drown a patient with 30 mL per kg fluid!

Marik

Malbrain

2017

Anaesthesiol Intensive Ther

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“…1. A retrospective study by Marik et al [79] on the use of vitamin C with thiamine and hydrocortisone for the treatment of sepsis and septic shock showed a significant difference in mortality between the treated (n = 47) and controlled groups (n = 47). This suggests that the intervention may reduce mortality of patients with severe sepsis and septic shock.…”

Section: Sepsis and Septic Shockmentioning

confidence: 99%

Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS). This review aims to explore analytical methodologies of thiamine compound quantification and highlight similarities, variances and limitations of current techniques and how they may be relevant to patients. Content: An electronic search of Medline, PubMed and Embase databases for original articles published in peerreviewed journals was conducted. MethodsNow was used to search for published analytical methods of thiamine compounds. Keywords for all databases included "thiamine and its phosphate esters", "thiamine methodology" and terms related to critical illness. Enquiries were also made to six external quality assurance (EQA) programme organisations for the inclusion of thiamine measurement.

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“…In addition, it is an important antioxidant in the aqueous of the body (15,16). Vitamin C supplementations deficiency reduces cellular immunity and increase duration of some diseases (11,17). Unfortunately, to the authors' best knowledge, there were few studies and only one study was completely related (18) and evaluated the effectiveness of vitamin C supplementations in treating UTIs.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study

Yousefichaijan

Goudarzi

Rezagholizamenjany

et al. 2018

Arch Pediatr Infect Dis

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Background: Urinary tract infections (UTIs) as a urological disorder occur in 1% -3% of females and 1% of males. This disease can induce severe complications such as pyelonephritis. Objectives: The current study aimed at evaluating the efficacy of vitamin C supplementation on UTI in children. Methods: The current clinical trial was conducted on 152 female children with UTI admitted to Amir-Kabir hospital, Arak, Iran. The cases were randomly divided, based on blocked groups, into two treatment and control groups of 76 patients. The subjects were matched in terms of age, gender, and clinical signs and symptoms. The control group received only routine treatment of UTI, while the treatment group, in addition to the routine treatment received oral vitamin C supplementation tablet, for a 14-day period. Results: Dysuria, urine incontinence, fever, urinary urgency, and dribbling occurred significantly earlier in vitamin C supplemented individuals than the control ones, while abdominal pain, dimercaptosuccinic acid (DMSA) scan, and recurrent UTI were not different between the two groups. Conclusions: Vitamin C supplementation can control the symptoms of urinary tract infections, including fever, dysuria, urinary urgency, and dribbling urine.

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Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

Cited by 817 publications

References 83 publications

The SEP-1 quality mandate may be harmful: How to drown a patient with 30 mL per kg fluid!

The SEP-1 quality mandate may be harmful: How to drown a patient with 30 mL per kg fluid!

Vitamin B1 in critically ill patients: needs and challenges

Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study

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