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We recommend a single 20-mg dose of conivaptan as the preferred initial approach to treating patients with SIADH who are in the neurosurgical intensive care unit. The 24-hour natremic response should then dictate whether additional doses of conivaptan or other therapeutic interventions are required. We believe that such an approach is safe and will result in a controlled and predictable increase in the serum sodium concentration.

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Heparin-induced thrombocytopenia (HIT) is a prothrombotic state associated with anti-platelet factor 4 (PF4)/heparin antibodies, which cause platelet activation. The result is venous and occasionally arterial thrombosis. Treatment involves prompt cessation of