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Marik, Paul E.; Rivera, Racquel; Hooper, Michael H.; Khangoora, Vikramjit; Catravas, John D.

doi:10.1016/j.chest.2017.05.028

Cited by 7 publications

(9 citation statements)

References 6 publications

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“…There is no available literature evaluating serum vitamin C concentrations in patients with sepsis; however, it has been estimated that receiving 1.5 g of intravenous vitamin C every six hours results serum concentrations around 35.2 mg/L. 35 This estimated serum concentration is much lower than those found in patients receiving high-dose intravenous vitamin C; however, any change in the potential for interference with POC glucose measurements is unknown.…”

Section: Discussionmentioning

confidence: 99%

Impact of High-Dose Intravenous Vitamin C for Treatment of Sepsis on Point-of-Care Blood Glucose Readings

Howell

Parrett

Malcom

2019

J Diabetes Sci Technol

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Background: Intravenous vitamin C therapy has been associated with reduced mortality in patients with sepsis. Of potential concern with this therapy are falsely elevated point-of-care (POC) blood glucose values vs laboratory analyzed (LA) readings. The purpose of this study was to compare POC and LA blood glucose measurements in patients receiving intravenous vitamin C therapy. Methods: All adults (≥18 years old) admitted from January 2017 to December 2018 who received at least two doses of intravenous vitamin C and had at least one paired blood glucose collection were eligible for inclusion. The primary endpoint was the accuracy in paired blood glucose values determined using the International Organization for Standardization (ISO) 15197:2013 criteria. Paired values were assessed for clinical impact using the Parkes consensus error grid analysis. A subgroup analysis was conducted to determine the impact of impaired renal function on outcomes. Results: Fourteen patients were included for analysis with 46 paired blood glucose levels. Compliance with ISO15197:2013 criteria was met in 34 (73.9%) paired values, which did not meet the minimum criteria for accuracy. Subgroup analysis showed that the paired values from patients with impaired renal function did not meet the minimum requirements for compliance, while those from patients without impaired renal function did. The Parkes error grid showed that the variation in POC measurements likely had minimal clinical impact. Conclusions: Our study suggests that most patients receiving vitamin C for sepsis may still be monitored at POC with the glucose meter used in our study with minimal clinical impact.

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Section: Discussionmentioning

confidence: 99%

Impact of High-Dose Intravenous Vitamin C for Treatment of Sepsis on Point-of-Care Blood Glucose Readings

Howell

Parrett

Malcom

2019

J Diabetes Sci Technol

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“…It has been suggested that high doses of intravenous vitamin C, together with hydrocortisone and Vitamin B1 improves outcomes in cases of sepsis as well as decreasing mortality in these patients (Marik et al, 2017). Ascorbic acid is an antioxidant and free radical scavenger that has anti-inflammatory properties, and serves as a cofactor in the generation of endogenous catecholamines.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and pharmacological management of COVID-19 patients admitted at a hospital in Nairobi, Kenya

Mariita¹,

Wanjala²,

Maina³

2021

Afr. J. Pharm. Pharmacol.

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COVID-19 is a novel viral disease with little known about its management. The Nairobi Hospital (TNH) has been involved in managing these patients. This study sought to describe the patients admitted in the hospital due to COVID-19, their management and outcomes. This was a retrospective review of COVID-19 patients admitted at TNH between March and October 2020. Demographic and clinical data, pharmacological management and outcomes of these patients was retrieved from the hospital electronic records, and analyzed. Results revealed that there were 326 study participants with a mean age (s.d.) of 47.1 (15.5) years, of whom 221(67.8%) were male. Those that were critically ill were 55(16.9%), while 186(57.1%) had mild/moderate disease. More than half of the participants had at least one co-morbidity, with hypertension and diabetes being predominant. Remdesivir was the commonest investigational drug and was administered to 39 patients. The patients were mainly managed with paracetamol (83.3%), ascorbic acid (79.8%), anticoagulants (64.4%), antihistamines and cough syrups (53.7%). Dexamethasone was the steroid of choice, having been used in 44% of the patients. Antibiotics were administered to 157 (48.4%) of the patients with Levofloxacin being the most prescribed. The mortality rate was 10% and was significantly associated with advanced age, having multiple comorbidities and severe illness. It was thus understood that management of COVID-19 inpatients at TNH was mainly supportive. There's need to emphasize on prevention measures especially among the elderly and those with multiple comorbidities.

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“…In contrast, a pharmacokinetic study of critically ill patients with multiple organ dysfunction demonstrated that vitamin C 2 g/day yielded serum levels of 50 µg/ml or lower . An editorial commented that vitamin C 6 g/day will result in vitamin C levels in the 200 µg/ml range. Although we did not obtain vitamin C concentrations to assess this relationship, our findings infer that the dose used in sepsis may have a low likelihood of clinically significant interference with POC BG level measures.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Point‐of‐Care Blood Glucose Level Measurements in Critically Ill Patients with Sepsis Receiving High‐Dose Intravenous Vitamin C

Smith

Brown

Manning³

et al. 2018

Pharmacotherapy

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Cited by 7 publications

References 6 publications

Impact of High-Dose Intravenous Vitamin C for Treatment of Sepsis on Point-of-Care Blood Glucose Readings

Impact of High-Dose Intravenous Vitamin C for Treatment of Sepsis on Point-of-Care Blood Glucose Readings

Characteristics and pharmacological management of COVID-19 patients admitted at a hospital in Nairobi, Kenya

Accuracy of Point‐of‐Care Blood Glucose Level Measurements in Critically Ill Patients with Sepsis Receiving High‐Dose Intravenous Vitamin C

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