Hydrogel-based holographic sensors and biosensors: past, present, and future

Lucío, María Isabel; Cubells-Gómez, Aitor; Maquieira, Ángel; Bañuls, María‐José

doi:10.1007/s00216-021-03746-1

Cited by 21 publications

(14 citation statements)

References 145 publications

(237 reference statements)

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“…Similarly, structural modification can also occur by immobilizing specific biological recognized elements (enzymes, antibodies) inside the hydrogel network. [221] Bioreceptors like enzymes, glucose, and antibodies are the main sensitive constituents that sustain the normal body functions in natural ways like controlling immunity. [222] For instance, glucose-activated hydrogels are fabricated by incorporating glucose-sensitive monomers like glucose oxidase enzymes, which trigger the pH value to different ranges stimulating physical changes, and are used in various biomedical applications like diabetes and glucose-responsive insulin delivery.…”

Section: Biologically Activementioning

confidence: 99%

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Additive manufacturing of smart polymeric composites: Literature review and future perspectives

2022

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The latest developments in smart systems for improved human lives with advanced biomedical devices have evolved out of multi‐disciplinary scientific studies, including medicine, biology, material sciences, design, manufacturing, artificial intelligence, microelectronics, and so forth. The growth of such intelligent systems is primarily possible with innovative materials, which demonstrate the response to various external stimuli like temperature, heat, moisture, light, electromagnetic field, and chemical alteration. Such materials have been recently fabricated using different additive manufacturing techniques to devise personalized unique, complex, and novel structures that can adjust to external conditions over time and are specifically attributed to 4D printing. Novel materials that can further improve such systems continued to be explored and employed. This review paper investigates the additive manufacturing of functional polymer nanocomposites, which offer compliant structures with flexible manufacturing processes with high strength, low cost, and long‐term stability. This study aims to deliver a comprehensive and deep understanding of the latest developments in materials, design, manufacturing, fundamental mechanisms involved, and future possibilities in this area of research.

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Section: Biologically Activementioning

confidence: 99%

“…Similarly, structural modification can also occur by immobilizing specific biological recognized elements (enzymes, antibodies) inside the hydrogel network. [ 221 ]…”

Section: Smart Materials For 4d Printingmentioning

confidence: 99%

Additive manufacturing of smart polymeric composites: Literature review and future perspectives

2022

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“…So far, various hydrophilic and hydrophobic polymers have been used for the fabrication of holographic sensors including gelatin, poly(2-hydroxyethyl methacrylate) (pHEMA), poly(acrylamide) (pAAM), and polyvinyl alcohol (PVA). Their application includes humidity, temperature, and pressure sensors, as well as glucose, lactate, electrolytes, and pH chemical sensors [ 11 ]. However, there are very few examples using bioreceptors, mainly antibodies, to achieve holographic biosensing, with their use for nucleic acid hybridizations not being reported.…”

Section: Introductionmentioning

confidence: 99%

Surface Micro-Patterned Biofunctionalized Hydrogel for Direct Nucleic Acid Hybridization Detection

et al. 2023

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The present research is focused on the development of a biofunctionalized hydrogel with a surface diffractive micropattern as a label-free biosensing platform. The biosensors described in this paper were fabricated with a holographic recording of polyethylene terephthalate (PET) surface micro-structures, which were then transferred into a hydrogel material. Acrylamide-based hydrogels were obtained with free radical polymerization, and propargyl acrylate was added as a comonomer, which allowed for covalent immobilization of thiolated oligonucleotide probes into the hydrogel network, via thiol-yne photoclick chemistry. The comonomer was shown to significantly contribute to the immobilization of the probes based on fluorescence imaging. Two different immobilization approaches were demonstrated: during or after hydrogel synthesis. The second approach showed better loading capacity of the bioreceptor groups. Diffraction efficiency measurements of hydrogel gratings at 532 nm showed a selective response reaching a limit of detection in the complementary DNA strand of 2.47 µM. The label-free biosensor as designed could significantly contribute to direct and accurate analysis in medical diagnosis as it is cheap, easy to fabricate, and works without the need for further reagents.

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“…Environmental researchers have seen the potential of OHs and applied them to pollutant detection [6,30] , particularly for the fast and inexpensive in situ detection of environmental pollutants. How-ever, OH sensor application studies primarily concentrate on biological and medical testing [31,32] . Therefore, there is currently a lack of reviews and perspective studies on the applications of OHs in environmental sensing, particularly on the feasibility and design strategies for implementing OHs in the practical detection of environmental pollutants.…”

Section: Introductionmentioning

confidence: 99%

Application of optical hydrogels in environmental sensing

Yang

Sarkar

Xie

et al. 2023

Preprint

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The ever-increasing complexity of environmental pollutants urgently warrants the development of new detection technologies. In this context, sensors based on the optical properties of hydrogels enabling fast and easy in situ detection are attracting increasing attention. Herein, the target recognition and sensing mechanisms of two main types of optical hydrogels (OHs) are reviewed and discussed: photonic crystal hydrogels (PCHs) and fluorescent hydrogels (FHs). For PCHs, the environmental stimulus response, target receptors, inverse opal structures, and molecular imprinting techniques related to PCHs are reviewed and summarized. Furthermore, the different types of fluorophores (i.e., compound probes, biomacromolecules, quantum dots, and luminescent microbes) of FHs are summarized. Finally, the data from 138 papers about different OHs are extracted for secondary statistical analysis. The detection performance and potential of various OH types in different environmental pollutant detection scenarios are evaluated, and compared them to those obtained using the standard detection method. Based on this analysis, some possible development directions are proposed, including the fusion of various OHs, introduction of more hydrogel technologies from the biomedical field to the environmental pollutant detection field, and development of multifunctional sensor arrays.

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Hydrogel-based holographic sensors and biosensors: past, present, and future

Cited by 21 publications

References 145 publications

Additive manufacturing of smart polymeric composites: Literature review and future perspectives

Additive manufacturing of smart polymeric composites: Literature review and future perspectives

Surface Micro-Patterned Biofunctionalized Hydrogel for Direct Nucleic Acid Hybridization Detection

Application of optical hydrogels in environmental sensing

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