Hydrogel Biomaterials

Patel, Aavishkar A.; Mequanint, Kibret

doi:10.5772/24856

Cited by 55 publications

(50 citation statements)

References 76 publications

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“…The pH range occurring at physiological, pathological, or subcellular sites such as the stomach, intestine, endosome/lysosome, and tumour sites is used for the formation of these hydrogels. Polymers used in this process are those with weak polyelectrolyte (polyacid, polybase) or polyampholyte sequences [116].PH sensitive hydrogels with ionic groups accept or donate protons with respect to changes in environmental pH change. The degree of ionization (pKa or pKb) changes in response to pH change changes.…”

Section: Ph Sensitive Hydrogelsmentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza

Zafar

Zhu

et al. 2017

Preprint

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Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. Aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. The therapeutical peptide and proteins are remarkable therapeutic agents in today's world that allows the treatment of severe, chronic and life-threatening diseases, such as diabetes, rheumatoid arthritis, hepatitis in an easy manner. Despite few limitations, hydrogels provide fine tuning of proteins and peptides delivery with enormous impact in clinical medicine. The primary objective of this article is to review current issues concerned with the therapeutics peptides and proteins and impact of remarkable properties of hydrogels on these therapeutic agents. Different routes for pharmaceutical peptides and proteins and superiority over other drugs candidates are presented. The article will also review literature concerning classification of hydrogels on different basis, polymers used, release mechanisms their physical and chemical characteristics and diverse applications.

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Section: Ph Sensitive Hydrogelsmentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza

Zafar

Zhu

et al. 2017

Preprint

View full text Add to dashboard Cite

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“…The amount of water absorbed may vary from around 10% to thousands of times the weight of the dry polymeric network, which may also be influenced by the capillary effect and osmotic pressure [130,131]. The water absorbing capacity makes hydrogels suitable for widespread applications in a variety of fields, including tissue engineering [132], the biomedical and pharmaceutical industry [133], and smart textiles [134].…”

Section: Hydrogel Technology Application Of Hydrogel In Functional Tementioning

confidence: 99%

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

2017

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Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense puritus and skin dryness. The pathogenesis for AD has not been fully understood to date. Complementary therapies are very popular as effective treatment for AD among clinical practitioners. This study presents a comprehensive review of published works associated with textiles-based complementary therapies for AD treatment such as wet-wrap dressing, functionalized textiles, and the application of hydrogel techniques in the textile industry to provide a better understanding of the development and design of new textiles-based transdermal therapies.

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“…Polymer hydrogel materials in the presence of ionic side residuals which could receive and provide H + in reply to an alteration in the pH value were studied by this research group [119]. At a given pH value, the amount of ions present in a pH-sensitive polymeric hydrogel, denoted as pK or PI, changes dramatically relative to another pH value.…”

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

Chuang

Chiang

Wong

et al. 2018

Advances in Materials Science and Engineering

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e treatment of articular cartilage damage is a major task in the medical science of orthopedics. Hydrogels possess the ability to form multifunctional cartilage grafts since they possess polymeric swellability upon immersion in an aqueous phase. Polymeric hydrogels are capable of physiological swelling and greasing, and they possess the mechanical behavior required for use as articular cartilage substitutes. e chondrogenic phenotype of these materials may be enhanced by embedding living cells. Artificial hydrogels fabricated from biologically derived and synthesized polymeric materials are also used as tissue-engineering scaffolds; with their controlled degradation profiles, the release of stimulatory growth factors can be achieved. In order to make use of these hydrogels, cartilage implants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. is paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. ese gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. is article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

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Hydrogel Biomaterials

Cited by 55 publications

References 76 publications

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

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