Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings

Biopolymers as Wound Healing Materials: Challenges and New Strategies

“…In a previous study has shown successful treatment with fucoidan-chitosan hydrogels which were tested in New Zealand rabbits with second degree burn (Sezer et al, 2008a). In another study, chitin/chitosan, fucoidan and alginate hydrogel blends were prepared and the granulation tissue and capillary formation were found to be increased in the first 7 days of the treatment of induced wounds (Murakami et al, 2010).…”

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

“…Due to their high water absorption rates, adhesion to the wound bed and increased pain during dressing changes, traditional dressings (e.g., gauze, cotton wool) are often employed as secondary dressings to allow the exudate drainage and to support the application of more effective products (e.g., skin substitutes) [77,115]. Traditional dressings have been largely replaced by modern dressings, which are capable of creating and maintaining a moist environment in the wound bed, ideally suited for cellular migration and proliferation [81,115,124,150,151]. A great deal of interest has been focused on advanced dressings with the ability to release bioactive substances directly into the wound bed [6,75,161,192].…”

“…Typically, these wounds require extensive hospitalization, labour intensive clinical procedures and costly wound care products, representing a major burden over total world healthcare expenditure [9,153,175]. Several skin therapies and wound care products have been developed and tested through pre-clinical and randomized controlled clinical trials with the ultimate goal of promoting the repair and regeneration of functional skin [44,49,84,86,88,103,124,189,195,212]. Traditional treatments are based on the use of grafts (which includes auto-, allo-and xenograft varieties), herbal and animalderived compounds, silver-containing and traditional dressings.…”

Novel Chitin and Chitosan Materials in Wound Dressing

“…The third group (water-soluble chitosan/heparin) showed nearly complete regeneration of appendage structure similar to normal in the dermis in contrast to control and second group with absence and less number of skin appendages, respectively (Kweon, Song & Park, 2003). For rapid wound healing, a hydrogel sheet composed of a blended powder of alginate, chitin/chitosan and fucoidan (ACF-HS; 60:20:2:4 w/w) has been developed as a functional wound dressing (Murakami et al, 2010). On application, ACF-HS was expected to effectively interact with and protect the wound in rats, providing a good moist healing environment with exudates.…”

“…Although normal rat wound repair was not stimulated by the application of ACF-HS, healing-impaired wound repair was significantly stimulated. Histological examination demonstrated significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with ACF-HS on day 7, as compared to those treated with calcium alginate fiber (Kaltostat; Convatec Ltd., Tokyo, Japan) and those left untreated (Murakami et al, 2010). PVA, water-soluble chitosan and glycerol based hydrogel was made by irradiation followed by freeze-thawing was evaluated as wound dressing (Yang et al, 2010).…”