Hydrogel Layers on the Surface of Polyester-Based Materials for Improvement of Their Biointeractions and Controlled Release of Proteins

Korzhikov-Vlakh, Viktor; Krylova, Maria N.; Sinitsyna, Ekaterina; Ivan’kova, Elena; Averianov, Ilia; Tennikova, Tatiana

doi:10.3390/polym8120418

Cited by 23 publications

(11 citation statements)

References 46 publications

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“…Specifically, the MTT assay revealed that the RGRs of PLA, PLA/MWCNT-Ag 0.1 , and PLA/MWCNT-Ag 0.2 after 72 h of incubation were 258.76%, 176.29%, and 126.39%, respectively. These specimens also had a cytotoxicity score of grade 0 (ISO 10993-5) [ 24 , 25 ], indicating no cytotoxicity. L929 fibroblasts exhibited a normal proliferation rate after incubation, with extracts of the PLA with low MWCNT-Ag content (0.1–0.2 phr).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Tsou

Yao

et al. 2017

Polymers

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A novel method was used to synthesize a nanosilver-doped multiwall carbon nanotube (MWCNT-Ag), and subsequently, the novel poly(lactic acid) (PLA)-and MWCNT-Ag-based biocompatible and antimicrobial nanocomposites were prepared by melt blending. Based on energy dispersive X-ray spectrometry images, an MWCNT-Ag was successfully synthesized. The effect of the MWCNT-Ag on the PLA bionanocomposites was investigated by evaluating their thermal and mechanical properties, antifungal activity, and cytotoxicity. The nanocomposites exhibited a high degree of biocompatibility with the MWCNT-Ag content, which was less than 0.3 phr. Furthermore, tensile strength testing, thermogravimetric analysis, differential scanning calorimetry, and antibacterial evaluation revealed that the tensile strength, thermostability, glass transition temperature, and antibacterial properties were enhanced by increasing the MWCNT-Ag content. Finally, hydrolysis analysis indicated that the low MWCNT-Ag content could increase the packing density of PLA.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Tsou

Yao

et al. 2017

Polymers

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“…To evaluate and compare the effect of polyester modification with polyelectrolyte layers on the surface hydrophobicity, the contact angles of corresponding films (PLA, PCL, PLA-PLys, PCL-PLys, PLA-PLys-Hep, PCL-PLys-Hep, PLA-(PLys-Hep) 2 , PCL-(PLys-Hep) 2 ) were measured. The films were prepared and characterized as described before [33]. Briefly, a 1.5 µL water drop was placed on the film surface, and the average static contact angle was determined using the drop analysis plugin (Biomedical Imaging Group, Lausanne, Switzerland) for ImageJ software during the first 30 s following the drop deposition.…”

Section: Evaluation Of Particles Physicochemical Properties Drug Entrapment Efficiency and Release Kineticsmentioning

confidence: 99%

Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility

et al. 2021

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A plethora of micro- and nanoparticle types are currently investigated for advanced ocular treatment due to improved drug retention times, higher bioavailability and better biocompatibility. Yet, comparative studies of both physicochemical and toxicological performance of these novel drug delivery systems are still rare. Herein, poly(L-lactic acid)- and poly(ε-caprolactone)-based micro- and nanoparticles were loaded with prednisolone as a model drug. The physicochemical properties of the particles were varied with respect to their hydrophilicity and size as well as their charge and the effect on prednisolone release was evaluated. The particle biocompatibility was assessed by a two-tier testing strategy, combining the EpiOcularTM eye irritation test and bovine corneal opacity and permeability assay. The biodegradable polyelectrolyte corona on the particles’ surface determined the surface charge and the release rate, enabling prednisolone release for at least 30 days. Thereby, the prednisolone release process was mainly governed by molecular diffusion. Finally, the developed particle formulations were found to be nontoxic in the tested range of concentrations.

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“…When dealing with polyesters’ biofunctionalization, one will face their relative hydrophobicity and lack of reactive groups for biomolecule attachment [27,28,29]. Only the terminal hydroxyl and carboxylic groups are available for modification without chain cleavage.…”

Section: Introductionmentioning

confidence: 99%

Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces

et al. 2018

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To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (“self-peptide” or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.

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Hydrogel Layers on the Surface of Polyester-Based Materials for Improvement of Their Biointeractions and Controlled Release of Proteins

Cited by 23 publications

References 46 publications

Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility

Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces

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