Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces

Abstract

To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (“self-peptide” or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.

Polypeptide Self-Assembled Nanoparticles as Delivery Systems for Polymyxins B and E

“…Recently, a so-called “self”-peptide, a fragment of the CD47 cell receptor, was discovered to serve as a signaling molecule that regulates phagocytosis [ 34 ]. In our previous work, we observed a decreased phagocytosis of PLA NPs modified with the “self”-peptide [ 46 ]. This concept was confirmed for the polypeptide systems by modifying the P(Glu- co - d Phe) NPs with a fluorescent dye and further modifying a fraction of them with the “self”-peptide.…”

PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

“…As a result, more and more research is devoted to their preparation for advanced materials for medical and regenerative applications to overcome the drawbacks arising from potential inflammatory side effects, including their high hydrophobicity, and low cell adhesion [9,10,11]. To eliminate such problems, current approaches include filling polyesters with nanoparticles of different nature [12,13] and their modification with other (macro)molecules of interest [14,15].…”

Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering

“…The PLA particle modification scheme is shown in Figure 2 A. A quantity of 500 mg of PLA particles were treated with 0.1 M NaOH solution (50 mL) to generate carboxyl groups ( Figure 2 (A1)) on the particle surface [ 46 ]. The hydrolysis was conducted for 30 min at room temperature, under stirring (350 rpm).…”