Hydrogel–Nanoparticle Hybrids for Biomedical Applications: Principles and Advantages

Sulaiman, Nur Shahirah; Hamzah, Nurasyikin; Zakaria, Siti Fatimah; Othman, Siti Fairuz Che; Suffian, Izzat Fahimuddin Mohamed

doi:10.2217/nnm-2020-0420

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Previous studies have shown that various hydrogels can promote healing of chronic wounds (64). can not only enhance cell growth, bone formation and anastomosis but also encapsulate cells, form scaffolds and act as drug carriers (65). MSCs-exo carried in hydrogels showed a reduced degradation rate.…”

Section: Conclusion and Future Perspectivementioning

confidence: 98%

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Jiang

et al. 2023

Front. Immunol.

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Diabetic foot is one of the most common complications of diabetes, requiring repeated surgical interventions and leading to amputation. In the absence of effective drugs, new treatments need to be explored. Previous studies have found that stem cell transplantation can promote the healing of chronic diabetic wounds. However, safety issues have limited the clinical application of this technique. Recently, the performance of mesenchymal stem cells after transplantation has been increasingly attributed to their production of exocrine functional derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned media. EVs contain a variety of cellular molecules, including RNA, DNA and proteins, which facilitate the exchange of information between cells. EVs have several advantages over parental stem cells, including a high safety profile, no immune response, fewer ethical concerns, and a reduced likelihood of embolism formation and carcinogenesis. In this paper, we summarize the current knowledge of mesenchymal stem cell-derived EVs in accelerating diabetic wound healing, as well as their potential clinic applications.

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Section: Conclusion and Future Perspectivementioning

confidence: 98%

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Jiang

et al. 2023

Front. Immunol.

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“…The result underpins that the nanoparticles could deliver a drug directly to the tumor cells, significantly reducing tumor growth and increasing survival rates in the mice ( Peng et al, 2019 ). The use of hydrogel nanoparticles could be used to deliver a drug directly to the tumor cells, resulting in significantly reduced tumor growth and increased survival rates in mice ( Biondi et al, 2015 ; Nolan et al, 2018 ; Rafieian et al, 2019 ; Jiang et al, 2020 ; Nadtoka et al, 2020 ; Stojkovska et al, 2020 ; Clasky et al, 2021 ; Sulaiman et al, 2021 ; Nunes et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Nano-sized warriors: zinc chromium vanadate nanoparticles as a dual solution for eradicating waterborne enterobacteriaceae and fighting cancer

Rehman,

Alahmari,

Aldossary

et al. 2023

Front. Pharmacol.

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The revolution of biomedical applications has opened new avenues for nanotechnology. Zinc Chromium vanadate nanoparticles (VCrZnO4 NPs) have emerged as an up-and-coming candidate, with their exceptional physical and chemical properties setting them apart. In this study, a one-pot solvothermal method was employed to synthesize VCrZnO4 NPs, followed by a comprehensive structural and morphological analysis using a variety of techniques, including X-Ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, Energy-dispersive X-ray, and X-ray photoelectron spectroscopy. These techniques confirmed the crystallinity of the NPs. The VCrZnO4 NPs were tested for their antibacterial activity against primary contaminants such as Enterobacteriaceae, including Shigella flexneri, Salmonella cholerasis, and Escherichia coli, commonly found in hospital settings, using the broth dilution technique. The results indicated a stronger antibacterial activity of VCrZnO4 NPs against Shigella and Salmonella than E. coli. Electron microscopy showed that the NPs caused severe damage to the bacterial cell wall and membrane, leading to cell death. In addition, the study evaluated the anticancer activities of the metal complexes in vitro using colorectal cancer cells (HCT-116) and cervical cancer cells (HELA), along with non-cancer cells and human embryonic kidney cells (HEK-293). A vanadium complex demonstrated efficient anticancer effects with half-inhibitory concentrations (IC50) of 38.50+3.50 g/mL for HCT-116 cells and 42.25+4.15 g/mL for HELA cells. This study highlights the potential of Zinc Chromium vanadate nanoparticles as promising candidates for antibacterial and anticancer applications. Various advanced characterization techniques were used to analyze the properties of nanomaterials, which may help develop more effective and safer antibacterial and anticancer agents in the future.

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“…The latter modification gives rise to hydrogel nanocomposite systems, a composite material with physically or covalently embedded nanoparticles or nanostructures within a crosslinked polymer, that can act as drug carriers, impart responsiveness to external stimuli, like to an alternating magnetic field (AMF), and increase sorption of hydrophobic contaminants, among others. [38][39][40][41][42] Hydrogel nanocomposites possess characteristics of the individual hydrogel components (i.e., high solvent content, high porosity/permeability, ability to absorb molecules and their controlled release) with those of the entrapped nanoparticles (i.e., electrical conductivity, mechanical reinforcement, magnetic features, catalytic activity, etc.) thereby creating unique materials with synergistic properties that cannot be achieved by either individual component alone.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

Gutiérrez

Frazar

Klaus

et al. 2021

Adv Healthcare Materials

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Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification, and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: 1) preventing exposures to environmental contaminants, 2) prophylactic treatments to prevent chronic disease initiation, and 3) treating chronic diseases after they have developed.

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Hydrogel–Nanoparticle Hybrids for Biomedical Applications: Principles and Advantages

Cited by 5 publications

References 26 publications

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Nano-sized warriors: zinc chromium vanadate nanoparticles as a dual solution for eradicating waterborne enterobacteriaceae and fighting cancer

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

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