Hydrogel Preparation Technologies: Relevance Kinetics, Thermodynamics and Scaling up Aspects

Sayed, Marwa M. El

doi:10.1007/s10924-019-01376-4

Cited by 76 publications

(50 citation statements)

References 95 publications

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“…Due to the special properties of hydrogels, these polymers can be used in a wide diversity of products like super-absorbent polymers, tissue engineering, contact lenses, drug delivery, and biotechnological devices [126]. These polymers have the characteristics to increase, decrease, assign and discharge compounds when exposed to variations in particular environmental parameters such as temperature, ionic concentration, light intensity, pH, pressure or even at the effect of particular biomarkers [127,128]. Two distinct hydrogel categories are known, synthetic and natural hydrogels.…”

Section: Major Applications Of Iamentioning

confidence: 99%

Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers

2019

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Biomass, the only source of renewable organic carbon on Earth, offers an efficient substrate for bio-based organic acid production as an alternative to the leading petrochemical industry based on non-renewable resources. Itaconic acid (IA) is one of the most important organic acids that can be obtained from lignocellulose biomass. IA, a 5-C dicarboxylic acid, is a promising platform chemical with extensive applications; therefore, it is included in the top 12 building block chemicals by the US Department of Energy. Biotechnologically, IA production can take place through fermentation with fungi like Aspergillus terreus and Ustilago maydis strains or with metabolically engineered bacteria like Escherichia coli and Corynebacterium glutamicum. Bio-based IA represents a feasible substitute for petrochemically produced acrylic acid, paints, varnishes, biodegradable polymers, and other different organic compounds. IA and its derivatives, due to their trifunctional structure, support the synthesis of a wide range of innovative polymers through crosslinking, with applications in special hydrogels for water decontamination, targeted drug delivery (especially in cancer treatment), smart nanohydrogels in food applications, coatings, and elastomers. The present review summarizes the latest research regarding major IA production pathways, metabolic engineering procedures, and the synthesis and applications of novel polymeric materials.

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Section: Major Applications Of Iamentioning

confidence: 99%

Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers

2019

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“…Therefore, hydrogel can be used in many fields such as advanced material for biomedical, environmental, catalysis, and sensor applications. [1][2][3][4][5][6][7] In particular, hydrogels have proven themselves clever options in developing stimuli-responsive systems, because their chemistry permits modulating the properties by including responsiveness via sensitive chemical moieties. 8,9 A large variety of hydrogels has been synthesized to response to physical stimuli (temperature, pH, light), chemical stimuli (various ''signaling'' molecules), or biological stimuli (enzymes).…”

Section: Introductionmentioning

confidence: 99%

Stimuli Responsive Hydrogels: NIPAM/AAm/Carboxylic Acid Polymers

Işıkver

Saraydın

2019

Acta Chemica Iasi

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Stimuli-responsive hydrogels (SRH) were prepared by using monomers (i.e. N-isopropyl acrylamide; NIPAM and acrylamide; AAm), co-monomers (i.e. methacrylic acid; MPA or mesaconic acid; MFA) and a crosslinker (N, N’-methylene bisacrylamide; N-Bis). SRH have been prepared by thermal free radical polymerization reaction in aqueous solution. Spectroscopic and thermal analyses such as Fourier Transform Infrared Spectroscopy, thermogravimetric analysis and differential scanning calorimetry analysis were performed for SRH characterization. The equilibrium swelling studies by gravimetrically were carried out in different solvents, at the solutions, temperature, pH, and ionic strengths to determine their effect on swelling characteristic of the hydrogels. In addition, cycles equilibrium swelling studies were made with the solutions at different temperatures and at different pH. NIPAM/AAm hydrogel exhibits a lover critical solution temperature (LCST) at 28 oC, whereas NIPAM/AAm-MPA and NIPAM/AAm-MFA hydrogels exhibit a LCST at 31 C and 35 oC, respectively, and the LCST of NIPAM/AAm-MFA hydrogel is close to the body temperature.

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“…[21] These properties are determina-tive in the fate of the encapsulated bioagents during mechanical deformation. [22,23] Various strategies for hydrogel fabrication by means of crosslinkers and/or external stimuli has been reviewed at Figure 1A-E.…”

Section: Strategies For Hydrogel Preparationmentioning

confidence: 99%

Hydrogel‐Based 3D Bioprinting for Bone and Cartilage Tissue Engineering

Abdollahiyan

Oroojalian

Mokhtarzadeh

et al. 2020

Biotechnology Journal

112

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As a milestone in soft and hard tissue engineering, a precise control over the micropatterns of scaffolds has lightened new opportunities for the recapitulation of native body organs through three dimentional (3D) bioprinting approaches. Well-printable bioinks are prerequisites for the bioprinting of tissues/organs where hydrogels play a critical role. Despite the outstanding developments in 3D engineered microstructures, current printer devices suffer from the risk of exposing loaded living agents to mechanical (nozzle-based) and thermal (nozzle-free) stresses. Thus, tuning the rheological, physical, and mechanical properties of hydrogels is a promising solution to address these issues. The relationship between the mechanical characteristics of hydrogels and their printability is important to control printing quality and fidelity. Recent developments in defining this relationship have highlighted the decisive role of main additive manufacturing strategies. These strategies are applied to enhance the printing quality of scaffolds and determine the nurture of cellular morphology. In this regard, it is beneficial to use external and internal stabilization, photocurable biopolymers, and cooling substrates containing the printed scaffolds. The objective of this study is to review cutting-edge developments in hydrogel-type bioinks and discuss the optimum simulation of the zonal stratification in osteochondral and cartilage units.

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Hydrogel Preparation Technologies: Relevance Kinetics, Thermodynamics and Scaling up Aspects

Cited by 76 publications

References 95 publications

Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers

Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers

Stimuli Responsive Hydrogels: NIPAM/AAm/Carboxylic Acid Polymers

Hydrogel‐Based 3D Bioprinting for Bone and Cartilage Tissue Engineering

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