Hydrogels: a smart drug delivery device

Devi, Anita; Nautiyal, Ujjwal; kaur, Sarabjot; Komal, Komal

doi:10.21276/apjhs.2014.1.1s.19

Cited by 6 publications

(6 citation statements)

References 43 publications

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“…Hidrogel merupakan struktur tiga dimensi dari jaringan polimer hidrofilik yang saling terikat silang. Material ini memiliki kapasitas untuk menahan air di dalam struktur porinya (Devi et al, 2014). Pada pengembangan sistem penghantaran obat, model hidrogel IPN memiliki kelebihan dalam hal memberikan volume ruang kosong pada struktur tiga dimensinya yang memudahkan proses enkaspulasi obat (Archana et al, 2015).…”

Section: Pendahuluanunclassified

Pengukuran Efisiensi Penjerapan Captopril secara In Situ Loading dan Post Loading dalam Hidrogel Kitosan Termodifikasi Interpenetrating Polymer Network (IPN) melalui Kavitasi Sonikasi

Amalia

2022

WARTA AKAB

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Captopril merupakan obat antihipertensi yang memiliki waktu paruh biologis yang pendek dan bioavailabilitas yang rendah. Suatu matriks hidrogel berbasis kitosan termodifikasi interpenetrating polymer network (IPN) telah berhasil disintesis dan dipelajari enkapsulasinya terhadap captopril. Penelitian ini dilakukan untuk mengukur efisiensi enkapsulasi captopril in situ loading dengan memanfaatkan teknik ultrasonikasi dan efisiensi enkapsulasi captopril post loading dengan memanfaatkan teknik difusi pelarut. Metode yang dipilih disesuaikan dengan cara loading captopril di dalam hidrogel. Penentuan nilai efisiensi enkapsulasi dilakukan melalui metode pengukuran persen efisiensi enkapsulasi dalam cairan asam menggunakan spektrofotometer UV-Vis. Hasilnya menunjukkan captopril yang dienkapsulasi dengan metode in situ loading memiliki nilai efisiensi enkapsulasi dengan rentang 67 – 84%, sedangkan captopril yang dienkapsulasi dengan metode post loading memiliki nilai efisiensi enkapsulasi dengan rentang 69 – 91%. Efisiensi enkapsulasi terkecil pada masing-masing metode in situ loading dan post loading berturut-turut dimiliki oleh hidrogel terikat silang (67 ± 8,10%) dan hidrogel full-IPN (69 ± 3,87%). Matriks hidrogel IPN yang memiliki rongga rigid, kekuatan ultasonikasi yang lemah, dan ukuran rongga yang terbentuk dari sintesis hidrogel menjadi faktor penentu pengukuran efisiensi enkapsulasi. Optimalisasi metode ultrasonikasi seperti penggunaan energi, waktu sonikasi, dan suhu diperlukan untuk memaksimalkan pengukuran efisiensi enkapsulasi in situ loading.

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Section: Pendahuluanunclassified

Pengukuran Efisiensi Penjerapan Captopril secara In Situ Loading dan Post Loading dalam Hidrogel Kitosan Termodifikasi Interpenetrating Polymer Network (IPN) melalui Kavitasi Sonikasi

Amalia

2022

WARTA AKAB

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“…They are classified into two types; upper critical solution temperature polymers (UCST), those that respond positively to the temperature, and lower critical solution temperature (LCST), those that react negatively to temperature 11,12 . The LCST polymer‐based thermosensitive hydrogel is hydrophobic while UCST polymers based is hydrophilic, while, we can change the solubility nature of both types of the hydrogel by varying the quantity of LCST and UCST polymers during the synthesis phase 13,14 …”

Section: Introductionmentioning

confidence: 99%

“…11,12 The LCST polymer-based thermosensitive hydrogel is hydrophobic while UCST polymers based is hydrophilic, while, we can change the solubility nature of both types of the hydrogel by varying the quantity of LCST and UCST polymers during the synthesis phase. 13,14 Oral and intravascular routes of drug administration are common in the field of drug delivery due to their effectiveness and convenience. However, both routes have several limitations, including low sustained release, poor targeted drug delivery, and side effects.…”

mentioning

confidence: 99%

“…[9][10][11] To overcome these challenges, researchers attempted trials on thermosensitive hydrogels in the drug delivery area, Whereas the literature highlighted that thermosensitive hydrogels are green materials with low side effects with desired drug administration characteristics. 12,13 Due to their sol-gel qualities, thermosensitive hydrogels may be applied anywhere in the human body. While at body temperature, it may store different hydrophilic and hydrophilic drugs in the matrix for prolonged release.…”

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confidence: 99%

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Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Khan,

Arbab,

Khan

et al. 2023

MedComm – Biomaterials and Applications

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The scientific community has widely recognized thermosensitive hydrogels as highly biocompatible material with immense potential in drug delivery systems. When the temperature of these hydrogels approaches that of human body, a phase change occurs, enhancing their usefulness in a range of medical scenarios. This review article highlighted the background of thermosensitive hydrogels, their properties, and their applications in transdermal, oral, ophthalmic, intravaginal, nasal, rectal, cancer therapy, and cell‐loaded drug delivery systems. The literature suggests numerous advantages of these hydrogels over conventional drug delivery systems and find applications in various fields, such as therapeutic systems, filling processes, and sustained drug delivery systems. One of their key benefits is the ability to eliminate invasive procedures like surgery, providing a noninvasive alternative for drug administration. Moreover, they streamline the formulation process for both hydrophilic and hydrophobic drug delivery systems, simplifying the development of effective treatments. The thermosensitive hydrogels have been found to be green materials with negligible side effects and desirable drug delivery properties. The thermosensitive hydrogel's sustained‐release characteristics, immunogenicity, and biodegradability have also gained increased interest. Some of the disadvantages of thermosensitive hydrogels include delayed temperature response, weak mechanical characteristics, and poor biocompatibility, which limits their potential use in drug delivery applications.

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“…The dexamethasone hydrogel insert is fluorescein-conjugated to aid with visualization. Polyethylene hydrogels are inert, biocompatible materials and have been used extensively in various biomedical applications, including in vivo drug delivery [25,26].…”

mentioning

confidence: 99%

Punctum and Canalicular Anatomy for hydrogel-based Intracanalicular Insert Technology

Tyson

Campbell²,

Biggins³

et al. 2020

Ther. Deliv.

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Aim: Despite advances in cataract surgery, postoperative ocular inflammation and pain occurs. To address compliance issues with topical corticosteroid administration, a hydrogel-based dexamethasone insert was developed for intracanalicular administration. The objective is to understand the anatomy to best administer the insert and learn how the anatomy and hydrogel properties help retain the insert in the canaliculus over time. Materials & methods: Human cadavers (n = 5) were dissected to assess dimensions of punctum and canaliculus as part of drug discovery and development. Results & conclusions: Mean measures for punctal diameter was 0.5 ± 0 mm and vertical canaliculi length was 2.4 ± 0.5 mm and width was 1.6 ± 0.5 mm. Vertical canalicular width was larger than the punctal opening, a critical understanding for placing and retaining intracanalicular inserts.

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Hydrogels: a smart drug delivery device

Cited by 6 publications

References 43 publications

Pengukuran Efisiensi Penjerapan Captopril secara In Situ Loading dan Post Loading dalam Hidrogel Kitosan Termodifikasi Interpenetrating Polymer Network (IPN) melalui Kavitasi Sonikasi

Pengukuran Efisiensi Penjerapan Captopril secara In Situ Loading dan Post Loading dalam Hidrogel Kitosan Termodifikasi Interpenetrating Polymer Network (IPN) melalui Kavitasi Sonikasi

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Punctum and Canalicular Anatomy for hydrogel-based Intracanalicular Insert Technology

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