Hydrogels and their potential uses in burn wound management

Edwards, Jacky

doi:10.12968/bjon.2010.19.sup4.48419

Cited by 16 publications

(15 citation statements)

References 10 publications

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“…The lack of significant differences may be due to the fact that standard wound care using Ringer solution as well as modern wound dressings and compression therapy per se positively affects the wound healing by creating an optimized wound environment for proper wound healing (14). Thus a moist wound environment favours wound‐healing processes was established in the last decade because of the fact that in a moist wound natural enzymatic reactions can take place without disturbance (16).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and tissue compatibility of a 12‐week treatment of chronic venous leg ulcers with an octenidine based antiseptic – a randomized, double‐blind controlled study

Vanscheidt¹,

Harding²,

Téot³

et al. 2011

International Wound Journal

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The aim of this study was to evaluate the cytotoxic effect of octenidine dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, double-blind controlled clinical study focusing on its safe and effective use in chronic venous leg ulcers. In total, 126 male and female patients were treated with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a period of maximum 12 weeks. For the assessment of the wound-healing process, clinical outcome parameters were employed, that is, time span until 100% epithelization, wound status and the wound surface area were analysed. Side effects were recorded during the study period. The median time to complete ulcer healing was comparable between the OHP and Ringer solution groups (92 versus 87 days; P = 0·952), without being influenced by wound size or duration of the target ulcer (P-values: 0·947/0·978). In patients treated with OHP, fewer adverse events (AEs) were observed compared with the Ringer group (17% versus 29% of patients reported 20 versus 38 AEs). OHP is well suitable for the treatment of chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the wound healing in chronic venous ulcers.

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Section: Discussionmentioning

confidence: 99%

Effectiveness and tissue compatibility of a 12‐week treatment of chronic venous leg ulcers with an octenidine based antiseptic – a randomized, double‐blind controlled study

Vanscheidt¹,

Harding²,

Téot³

et al. 2011

International Wound Journal

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“…In total, 115 studies were identified from searching the medical literature. Independent scrutiny of titles and abstracts by two authors identified 25 potentially relevant articles, all of which were excluded for the following reasons: studies undertaken in the non-pre-hospital setting (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), in clinical laboratories (26)(27)(28)(29), involving animals (30)(31)(32)(33); or published in non-English language (34)(35)(36)(37).…”

Section: Resultsmentioning

confidence: 99%

“…For example, some Australian EMS services use HBD only where water is inaccessible (57,58) or stipulate based upon patient age and/or TBSA (59), whilst one suggests several alternatives all considered appropriate (60). Variations in Australian EMS practice are replicated in overseas jurisdictions ( Table 2 Agency Numbers: [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”

Section: Recommendations and Guidelines For Practicementioning

confidence: 99%

The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting: a systematic review of the literature

Goodwin

Spinks

Wasiak

2015

International Wound Journal

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The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language articles published through September 2014. Reference lists, conference proceedings and non-indexed academic journals were manually searched. A separate search was conducted using the Internet search engine Google to source additional studies from burns advisory agencies, first aid bodies, military institutions, manufacturer and paramedic websites. Two authors independently assessed study eligibility and relevance of non-traditional data forms for inclusion. Studies were independently assessed and included if Hydrogel-based burn dressings (HBD) were examined in first aid practices in the pre-hospital setting. A total of 129 studies were considered for inclusion, of which no pre-hospital studies were identified. The review highlights that current use of HBD in the pre-hospital setting appears to be driven by sources of information that do not reflect the paramedic environment. We recommend researchers in the pre-hospital settings undertake clinical trials in this field. More so, the review supports the need for expert consensus to identify key demographic, clinical and injury outcomes for clinicians and researchers undertaking further research into the use of dressings as a first aid measure.

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“…Now evidence is accumulating that sheet hydrogels are very useful in pain management, particularly in superficial burns, as the moisture bathes nerve endings and the smoothing and cooling nature of hydrogels helps to reduce wound pain. [88][89][90][91] However, they are not recommended for wounds with heavy exudate due to the low absorption rate, which might cause periwound maceration and bacterial proliferation. Some sheet dressings are difficult to handle because of the low mechanical strength, thereby affecting patient compliance.…”

Section: N-chloraminesmentioning

confidence: 99%

Effect of hydrogel grafting, water and surfactant wetting on the adherence of PET wound dressings

Ning

Logsetty

Ghughare

et al. 2014

Burns

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Traditional wound dressings, including cotton gauze, absorbent pads and bandages, can cause trauma and pain to wounds during dressing changes, leading to a variety of physical and psychosocial sequelae. The aim of this study was to adapt an in vitro model of adherence to evaluate the effects of various methods to theoretically reduce the adherence of wound dressings. Gelatin in liquid form was cast onto poly(ethylene terephthalate) (PET) fabric and allowed to solidify and progressively dry to simulate wound desiccation in the clinical setting. A 180° peel test of PET from the gelatin slab yielded adherence data of peeling energy. The peeling energy of PET increased with the drying time. It was possible to reduce the force by drying at 75% relative humidity (RH). After drying for 24h, either 500μL of water or surfactant solution was added onto the PET surface (16×60mm(2)). The peeling energy decreased dramatically with wetting and there was no significant difference between water and surfactant. As a long-term strategy for decreasing adherence, a thin layer of polyacrylamide (PAM) hydrogel was deposited onto PET fabric via UV irradiation. This resulted in a much lower peeling energy without severely compromising fabric flexibility. This hydrogel layer could also serve as a reservoir for bioactive and antimicrobial agents which could be sustainably released to create a microbe-free microenvironment for optimized wound healing.

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Hydrogels and their potential uses in burn wound management

Cited by 16 publications

References 10 publications

Effectiveness and tissue compatibility of a 12‐week treatment of chronic venous leg ulcers with an octenidine based antiseptic – a randomized, double‐blind controlled study

Effectiveness and tissue compatibility of a 12‐week treatment of chronic venous leg ulcers with an octenidine based antiseptic – a randomized, double‐blind controlled study

The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting: a systematic review of the literature

Effect of hydrogel grafting, water and surfactant wetting on the adherence of PET wound dressings

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