Hydrogels as intelligent materials: A brief review of synthesis, properties and applications

Mahinroosta, Mostafa; Farsangi, Zohreh Jomeh; Allahverdi, Ali; Shakoori, Zahra

doi:10.1016/j.mtchem.2018.02.004

Cited by 435 publications

(254 citation statements)

References 207 publications

Supporting

Mentioning

251

Contrasting

Unclassified

Order By: Relevance

“…Nanogels consist of hydrogels composed of particles within the range of nanometers [81]. Hydrogels are three-dimensional cross-linked polymeric networks and have the capacity to uptake high amount of water or biological fluid [82]. Their loading with drugs is spontaneous and the production does not require mechanical energy or organic solvents [83].…”

Section: Nanogelsmentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

102

View full text Add to dashboard Cite

Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

show abstract

Section: Nanogelsmentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

102

View full text Add to dashboard Cite

show abstract

“…Hydrogels are three-dimensional, water-swollen polymer networks. [1][2][3] Although waterinsoluble due to strong physical or chemical cross-linking, hydrogels may retain large amounts of water, thus providing a versatile matrix with tissue-like mechanical properties. [4] Thanks to these features, hydrogels have found applications in the area of tissue engineering, [5] biosensors, [6,7] chemical analysis, [8] agriculture, [9] and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Castiglione

Casalegno

Ferro

et al. 2019

Journal of Controlled Release

View full text Add to dashboard Cite

Polymeric hydrogels are promising candidates for drug delivery applications, thanks to their ability to encapsulate, transport and release a wide range of chemicals. The successful application of these materials requires a deep understanding of the mechanisms governing solute transport at the nanoscale and its impact on release kinetics. In this work, we investigate the translational diffusion of ibuprofen loaded in anionic agarose-carbomer (AC) hydrogels by 1 H high resolution magic angle spinning (HR-MAS) NMR spectroscopy, and compare it to its macroscopic release kinetics. The analysis of the experimental NMR data provides the first evidence of superdiffusion for ibuprofen in AC hydrogels. Superdiffusive transport is observed in the majority of our samples, especially those with the smallest mesh size (7 nm) and highest ibuprofen concentrations (90-120 mg/mL). This outcome is rationalized in terms of heavy-tailed distributions of spatial displacements (Lèvy flights) and of waiting times, which depend on the nanoscopic structural heterogeneity of the gels and the strong but reversible association between ibuprofen and the agarose matrix.

show abstract

“…pH‐sensitive products respond to pHs more effectively when pH values are close to the pKa of the material . Particularly, when the molecules are charged, they generate electrostatic repulsions that lead to increase of the hydrodynamic volumes of the chains and modification of the solubility of the polymer in the medium . The polymers employed most commonly as pH‐sensitive materials are based on polyacrylamide (PAAm), polyacrylic acid (PAA), poly(methacrylic acid) (PMAA), poly(diethylaminoethyl methacrylate) (PDEAEMA), and poly(dimethylaminoethyl methacrylate) (PDMAEMA) …”

Section: Introductionmentioning

confidence: 99%

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Alves

Melo

et al. 2019

Macro Reaction Engineering

View full text Add to dashboard Cite

Schistosomiasis is a parasitic disease that affects millions of people, especially low‐income people, and is considered a major public health problem in underdeveloped countries. The drug used most often for the treatment of the disease is praziquantel (PZQ), which has a strong and characteristic bitter taste that makes treatment of children inconvenient. For this reason, the present work investigates the development of smart pH‐sensitive polymer microparticles produced through suspension polymerizations to be used as vehicles for the controlled release of praziquantel in the body. The microparticles are produced through copolymerization of methyl methacrylate and the cationic comonomers diethylaminoethyl methacrylate or dimethylaminoethyl methacrylate. The obtained results indicate that microparticles with sizes in the range of 10–1100 µm can be formed successfully, allowing high PZQ encapsulation efficiencies (>80%). Zeta potential analyses and drug release assays confirm the pH‐sensitive responses of the cationic copolymers, leading to effective release of PZQ (around 80% in pH 1.2) in acidic media that simulate the organic fluids present in the stomach.

show abstract

Hydrogels as intelligent materials: A brief review of synthesis, properties and applications

Cited by 435 publications

References 207 publications

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Contact Info

Product

Resources

About