Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery

Chyzy, Adam; Tomczykowa, Monika; Płońska‐Brzezińska, Marta E.

doi:10.3390/ma13010188

Cited by 96 publications

(59 citation statements)

References 240 publications

(403 reference statements)

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“…as a reaction to external stimuli, and are capable of showing switchable sol-gel transition on the application of different external stimuli. Generally, the hydrogels are divided into physical, chemical or biological responsive hydrogels, ( Figure 7) as they react to [76,77]: (i) physical stimuli: temperature, pressure, light, electric or magnetic fields, (ii) chemical stimuli: pH, chemical agents, ionic factors, etc., or (iii) biological stimuli: proteins, enzyme, glucose, etc. Smart hydrogels have morphological and functional characteristics that change in the presence of various external stimuli, essential properties for the applications in the field of drug delivery systems.…”

Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

137

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

137

View full text Add to dashboard Cite

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“…Based on the size and shape, hydrogels can be divided into macro‐hydrogel (columnar, globose, fibrous, membranous, porous spongy, etc.) and microhydrogel (nanoscale and micron scale) 64 . Macro‐hydrogels refer to gels that are larger than millimeters in size, which can be implanted via injection or surgical incision and plays an important role in cancer treatment.…”

Section: The Classification Preparation Of Hydrogel and Its Advantamentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

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Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

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“…Recently, several studies demonstrated that locally injectable hydrogels have the potential for efficient local and long-term delivery of OVs [ 43 , 44 ]. In particular, nanohydrogel, as a nano-dimensional hydrogel, integrates the advantages from both hydrogel systems and nanoparticle systems, thereby, it has been extensively developed and investigated as drug carrier due to their biocompatibility, high water holding capacity, tissue-like mechanical properties, biocompatibility, while also displacing long circulation time in the blood stream, modifiable surface for targeting, and possibility for systemic administration [ 45 ]. However, there are no previous studies have used nanohydrogel as systemic delivery system for OVs.…”

Section: Introductionmentioning

confidence: 99%

Development of a New Hyaluronic Acid Based Redox-Responsive Nanohydrogel for the Encapsulation of Oncolytic Viruses for Cancer Immunotherapy

et al. 2021

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Oncolytic viruses (OVs) are emerging as promising and potential anti-cancer therapeutic agents, not only able to kill cancer cells directly by selective intracellular viral replication, but also to promote an immune response against tumor. Unfortunately, the bioavailability under systemic administration of OVs is limited because of undesired inactivation caused by host immune system and neutralizing antibodies in the bloodstream. To address this issue, a novel hyaluronic acid based redox responsive nanohydrogel was developed in this study as delivery system for OVs, with the aim to protect the OVs following systemic administration. The nanohydrogel was formulated by water in oil (W/O) nanoemulsion method and cross-linked by disulfide bonds derived from the thiol groups of synthesized thiolated hyaluronic acid. One DNA OV Ad[I/PPT-E1A] and one RNA OV Rigvir® ECHO-7 were encapsulated into the developed nanohydrogel, respectively, in view of their potential of immunovirotherapy to treat cancers. The nanohydrogels showed particle size of approximately 300–400 nm and negative zeta potential of around −13 mV by dynamic light scattering (DLS). A uniform spherical shape of the nanohydrogel was observed under the scanning electron microscope (SEM) and transmission electron microscope (TEM), especially, the successfully loading of OV into nanohydrogel was revealed by TEM. The crosslinking between the hyaluronic acid chains was confirmed by the appearance of new peak assigned to disulfide bond in Raman spectrum. Furthermore, the redox responsive ability of the nanohydrogel was determined by incubating the nanohydrogel into phosphate buffered saline (PBS) pH 7.4 with 10 μM or 10 mM glutathione at 37 °C which stimulate the normal physiological environment (extracellular) or reductive environment (intracellular or tumoral). The relative turbidity of the sample was real time monitored by DLS which indicated that the nanohydrogel could rapidly degrade within 10 h in the reductive environment due to the cleavage of disulfide bonds, while maintaining the stability in the normal physiological environment after 5 days. Additionally, in vitro cytotoxicity assays demonstrated a good oncolytic activity of OVs-loaded nanohydrogel against the specific cancer cell lines. Overall, the results indicated that the developed nanohydrogel is a delivery system appropriate for viral drugs, due to its hydrophilic and porous nature, and also thanks to its capacity to maintain the stability and activity of encapsulated viruses. Thus, nanohydrogel can be considered as a promising candidate carrier for systemic administration of oncolytic immunovirotherapy.

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Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery

Cited by 96 publications

References 240 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Development of a New Hyaluronic Acid Based Redox-Responsive Nanohydrogel for the Encapsulation of Oncolytic Viruses for Cancer Immunotherapy

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