Hydrogels for Modified-release Drug Delivery Systems

Zielińska, Aleksandra; Eder, Piotr; Rannier, Lucas; Cardoso, Juliana Cordeiro; Severino, Patrícia; Silva, Amélia M.; Souto, Eliana B.

doi:10.2174/1381612828666211230114755

Cited by 20 publications

(7 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The biomembranes GEL, GELSA, and GELAC started swelling as soon after immersion, with rapid mass gain. The swelling capacity of the biomembranes may have been influenced by the hydrophilic group (OH) found in the polymer matrix, the density of crosslinks, and the presence of pores [ 41 ] since there is the possibility of water binding directly to the polymeric chains or filling the spaces in the pores [ 42 , 43 ]. It is also likely that gelatin, interacting with the biomembrane compounds, keeps its molecules further apart, allowing water to enter.…”

Section: Resultsmentioning

confidence: 99%

Hydrophilic Scaffolds Containing Extracts of Stryphnodendron adstringens and Abarema cochliacarpa for Wound Healing: In Vivo Proofs of Concept

et al. 2022

View full text Add to dashboard Cite

The present work aimed to evaluate the healing effect of hydrophilic polymeric resorbable biomembrane scaffolds containing plant extracts obtained from two different species, both popularly known as Stryphnodendron adstringens or Barbatimão. The hydrogel-based scaffolds were characterized and submitted to biological tests using Wistar rats to evaluate their healing capacity. The wound retraction index and the evaluation of the inflammatory process and tissue collagenization were recorded. The extracts showed antioxidant activity with IC50 between 10 and 20 µg/mL (DPPH assay) and 4–6 mmol Trolox/g (FRAP assay). The extract of Stryphnodendron adstringens (SA) presented gallocatechin, epigallocatechin, and O-methylpigalocatechin, while the extract of Abarema cochliacarpa (AC) presented catechin, dimers of procyanidins, di-O-hydroxide, O-deoxyhexosi-hexoside, and epicatechin. The membranes containing SA extract (GELSA) were more rigid, with a more intense color, but less thick, with a more compact structure and few pores. The membranes containing AC extract (GELAC) presented a mechanical profile like the gelatin membrane (GEL), with greater permeability to water vapor. The GELAC and GELSA membranes showed similar thermal degradation profiles. The wounds treated with the membranes containing the extracts obtained high levels of retraction of the wounds with values around 60% and 80% in three and seven days, respectively. These data indicate that the compounds of both species have promising biological activities in the repair process, showing that the extracts accelerated the healing process due to the lower intensity of the inflammatory reaction and the presence of compounds such as catechin and epigallocatechin.

show abstract

Section: Resultsmentioning

confidence: 99%

Hydrophilic Scaffolds Containing Extracts of Stryphnodendron adstringens and Abarema cochliacarpa for Wound Healing: In Vivo Proofs of Concept

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hydrogels developed in the third stage of development led to creating “smart hydrogels” [ 28 ]. Since the 1980s, hydrogels have been used for various biomedical disciplines like contact lenses, absorbent cotton, suture, and cell engineering [ 29 ], and biosensor, drug delivery, cell therapy, and 3D cell culture [ 27 ] to incorporate various conventional and novel formulations [ 18 , 29 ].…”

Section: Hydrogelsmentioning

confidence: 99%

“…A semi-solid state became advantageous for actual usage of the prescribed dose for applying in the skin. Pharmaceutical companies are gaining rapid attention or are increasingly interested in hydrogels due to their modified drug release [ 18 ]. Initially, many research studies were performed in hydrogels by simply incorporating various drugs in pure or dissolved in suitable solvents to the prepared hydrogel base.…”

Section: Introductionmentioning

confidence: 99%

Novel Hydrogels for Topical Applications: An Updated Comprehensive Review Based on Source

Almoshari

2022

Gels

View full text Add to dashboard Cite

Active pharmaceutical ingredients (API) or drugs are normally not delivered as pure chemical substances (for the prevention or the treatment of any diseases). APIs are still generally administered in prepared formulations, also known as dosage forms. Topical administration is widely used to deliver therapeutic agents locally because it is convenient and cost-effective. Since earlier civilizations, several types of topical semi-solid dosage forms have been commonly used in healthcare society to treat various skin diseases. A topical drug delivery system is designed primarily to treat local diseases by applying therapeutic agents to surface level parts of the body such as the skin, eyes, nose, and vaginal cavity. Nowadays, novel semi-solids can be used safely in pediatrics, geriatrics, and pregnant women without the possibility of causing any allergy reactions. The novel hydrogels are being used in a wide range of applications. At first, numerous hydrogel research studies were carried out by simply adding various APIs in pure form or dissolved in various solvents to the prepared hydrogel base. However, numerous research articles on novel hydrogels have been published in the last five to ten years. It is expected that novel hydrogels will be capable of controlling the APIs release pattern. Novel hydrogels are made up of novel formulations such as nanoparticles, nanoemulsions, microemulsions, liposomes, self-nano emulsifying drug delivery systems, cubosomes, and so on. This review focus on some novel formulations incorporated in the hydrogel prepared with natural and synthetic polymers.

show abstract

“…A rise in the utilization of hydrogel products stands as a significant stimulant for expanding the hydrogel market over the next few years ( Cascone and Lamberti, 2020 ). Commercial hydrogels can be obtained for diverse drug delivery applications, including localized delivery through the parenteral route, stimuli-responsive hydrogels for oral delivery, and controlled release properties for transdermal patches ( Shi and Li, 2005 ; Sharpe et al, 2014a ; Zielińska et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Commercial hydrogel product for drug delivery based on route of administration

Raeisi,

Farjadian

2024

Front. Chem.

View full text Add to dashboard Cite

Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant amounts of biological fluids or water. Hydrogels possess several favorable properties, including flexibility, stimulus-responsiveness, versatility, and structural composition. They can be categorized according to their sources, synthesis route, response to stimulus, and application. Controlling the cross-link density matrix and the hydrogels’ attraction to water while they’re swelling makes it easy to change their porous structure, which makes them ideal for drug delivery. Hydrogel in drug delivery can be achieved by various routes involving injectable, oral, buccal, vaginal, ocular, and transdermal administration routes. The hydrogel market is expected to grow from its 2019 valuation of USD 22.1 billion to USD 31.4 billion by 2027. Commercial hydrogels are helpful for various drug delivery applications, such as transdermal patches with controlled release characteristics, stimuli-responsive hydrogels for oral administration, and localized delivery via parenteral means. Here, we are mainly focused on the commercial hydrogel products used for drug delivery based on the described route of administration.

show abstract

Hydrogels for Modified-release Drug Delivery Systems

Cited by 20 publications

References 88 publications

Hydrophilic Scaffolds Containing Extracts of Stryphnodendron adstringens and Abarema cochliacarpa for Wound Healing: In Vivo Proofs of Concept

Hydrophilic Scaffolds Containing Extracts of Stryphnodendron adstringens and Abarema cochliacarpa for Wound Healing: In Vivo Proofs of Concept

Novel Hydrogels for Topical Applications: An Updated Comprehensive Review Based on Source

Commercial hydrogel product for drug delivery based on route of administration

Contact Info

Product

Resources

About