Hydrogels in endovascular embolization. I. Spherical particles of poly(2-hydroxyethyl methacrylate) and their medico-biological properties

Horák, Daniel; Švec, František; Kálal, J.; Гумаргалиева, К. З.; Adamyan, A. A.; Skuba, N. D.; Titova, Mariya; Trostenyuk, Nadezhda

doi:10.1016/0142-9612(86)90100-6

Cited by 67 publications

(23 citation statements)

References 4 publications

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“…While hydrophilic polymers serve well as stabilizers in water, hydrophobic poly-(dodecyl methacrylate) with a molecular weight of 4610 was used for inverse suspension polymerization of HEMA in decahydronaphthalene [51].…”

Section: Suspension Stabilizermentioning

confidence: 99%

Methacrylate‐based chromatographic media

Beneš

Horák

Švec³

2005

J of Separation Science

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This review summarizes the preparation and application of chromatographic separation media based on methacrylate monomers with a major focus on highly crosslinked macroporous beads prepared from 2-hydroxyethyl methacrylate and glycidyl methacrylate, respectively. The effects of process variables such as composition of the polymerization mixture that includes monomers, porogenic solvents, and free radical initiator, suspension stabilizer, reaction temperature, and stirring are detailed for both classical and templated suspension polymerization. In addition, specific features of the preparation of monodisperse beads are also discussed. The performance of methacrylate-based separation media is demonstrated on numerous separations in a variety of chromatographic modes.

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Section: Suspension Stabilizermentioning

confidence: 99%

Methacrylate‐based chromatographic media

Beneš

Horák

Švec³

2005

J of Separation Science

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“…Many polymers (i.e., cyanoacrylate) and polymer solvents [i.e., dimethyl sulfoxide (DMSO)] are cytotoxic in their liquid form, which can lead to an unwanted immune response and tissue inflammation. [7][8][9][10] The calcium alginate studies presented here are intended to assess the biocompatibility and mechanical stability of a wellknown material for a new application: endovascular polymer occlusion of vascular defects.…”

Section: Introductionmentioning

confidence: 99%

Calcium alginate gel: A biocompatible and mechanically stable polymer for endovascular embolization

Becker

Kipke

Brandon

2000

J. Biomed. Mater. Res.

212

148

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The development and optimization of calcium alginate for potential use in endovascular occlusion was investigated by testing its in vitro and in vivo mechanical stability and biocompatibility. The compressive resistance, rheology, and polymer yield of reacted alginate, and the polymer viscosity of unreacted alginate, were assessed. Biocompatibility was tested by injecting calcium alginate into the kidney capsule of rats. The reactivity of alginates with various structures and levels of purity were compared visually and histologically. Results suggest that calcium alginate is a biocompatible and mechanically stable gel for endovascular applications. Purified alginates exhibited compressive strength of 22 kPa and above at 40% compression, with no significant loss in elasticity. Purified alginate strength was significantly higher than that of crude alginates (p < 0.08). Purified alginates also exhibited significantly lower tissue reaction than crude alginates (p < 0.05). Of the alginates tested, purified high guluronic acid alginates (PHG) exhibited optimal strength and polymer yield, increased biocompatibility, and decreased viscosity. Clinical embolization treatments may be improved with the development of stable and biocompatible polymers such as calcium alginate. Possible uses of improved endovascular polymers include treating arteriovenous malformations (AVMs), aneurysms, blood flow to tumors, and vascular hemorrhaging.

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“…These particles have served as fillings for both benign and malign tumors and as preparations arresting profuse bleeding of various origins in clinical practice in Russia for more than 15 years. [10][11][12][13][14] In some cases, e.g., in hepatic and pancreatic tumors and hemorrhages, cylindrical particles, which are usually easier to administer, were used; on the other hand, for treatment of bronchial hemorrhage and giant angiodysplasia in the pelvic region, spherical particles are more beneficial. Embolization with poly(HEMA) particles is advantageous because their calibrated size enables selection of the embolus according to the diameter of the blood vessel lumen.…”

Section: Resultsmentioning

confidence: 99%

“…10 Cylindrical particles of medical purity, typically 30 cm in length, cut into pieces 10-25 mm long before application, were adjusted in 100-mL infusion bottles; spherical particles of 0.1 g weight and 0.5-0.8 mm diameter were adjusted in 10-mL vials in isotonic solution of sodium chloride and sterilized in an autoclave.…”

Section: Methodsmentioning

confidence: 99%

Targeted chemoembolization of tumors with poly(2-hydroxyethyl methacrylate) particles

Horák¹,

Guseinov²,

Вишневский³

et al. 2000

J. Biomed. Mater. Res.

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Thirty-four patients suffering from various kinds of tumors, including metastasis, were treated by selective embolization with both spherical and cylindrical poly(2-hydroxyethyl methacrylate) [poly(HEMA)] particles and topical chemotherapy. Treatment of a patient with carcinoid metastases in the liver is discussed. Immediately after embolization, 5-fluorouracil, and later, doxorubicin and Lipiodol, were selectively infused into the tumorous tissue for approximately 1 week. Patient received four cycles of this infusion. Chemoembolization proceeded against the background of anticoagulant therapy using small doses of heparin or its low-molecular-weight analogue, dalteparin. This was followed by transcutaneous transhepatic portography and embolization. Finally, the tumor-feeding artery and portal vein were sealed by a hydrogel. After 1.5 months, the affected liver lobe was resected. Although 4 years from the beginning of treatment, the patient is still alive. Embolization with poly(HEMA) hydrogel particles in conjunction with an anticancer drug infusion via catheter is recommended as an efficient method of tumor treatment. The therapeutic effect has been shown to be a function of ischemia and slow local infusion of drug into the tumor, and systemic drug levels can be kept low.

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Hydrogels in endovascular embolization. I. Spherical particles of poly(2-hydroxyethyl methacrylate) and their medico-biological properties

Cited by 67 publications

References 4 publications

Methacrylate‐based chromatographic media

Methacrylate‐based chromatographic media

Calcium alginate gel: A biocompatible and mechanically stable polymer for endovascular embolization

Targeted chemoembolization of tumors with poly(2-hydroxyethyl methacrylate) particles

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