Hydrogels of N-isopropylacrylamide copolymers with controlled release of a model protein

Smart Nanohydrogels for Controlled Release of Food Preservatives

“…So the collapsing of polymer nanoparticles happens in higher temperature due to more energy is required to destroy the hydrogen bonds. This behaviour was also observed with other hydrophilic copolymers, so Milašinović et al [124] observed a similar behaviour when increasing the hydrophilicity degree by increasing the percentage of itaconic acid.…”

“…There was no burst effect, but rather the pimaricin was released steadily. According to Milašinović et al [124], the absence of the initial burst suggests that the pimaricin is trapped in the nanogel structure, unlike the previous assayed nanogel in which significant amounts of pimaricin seem to remain exposed on the surface of the nanogel particles.…”

“…As explained in Section 1.4 on page 40 (Chapter 1), the physical properties (LCST) of PNIPA nanohydrogels can be modulated by copolymerization with hydrophilic monomers [164,57,124]. It is expected that adding AA will promote the formation of new hydrogen bonds with water.…”

“…[126]: (maximum latency, h) and α is a shape parameter related to the maximum slope of the response. 124 …”

Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel

“…Meanwhile, their biodegradation could also be enhanced (Hu et al, 2004). As a kind of unsaturated dicarboxylic acids, the structure of itaconic acid (IA) contains two carboxyl groups, which could significantly improve the pH-responsive ability of the obtained hydrogels synthesized by it (Milašinović et al, 2010). In our previous work, as the main constituent of pH-sensitive hydrogel, methoxyl poly(ethylene glycol)-PLA-acryloyl chloride (AC) amphiphilic macromonomer was successfully synthesized (Wang et al, 2012a).…”