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(2015) Application of traditional Chinese medicine preparation in targeting drug delivery system, Drug Delivery, 22:3, 258-265, DOI: 10.3109/10717544.2014 AbstractTargeting drug system (TDS) or targeted drug delivery system (TDDS) is a new kind of drug delivery system which could make drug to be directly concentrated on the target site with high curative effects and low side-effects. As the quintessence of Chinese culture, traditional Chinese medicine (TCM) has a large advantage in many disease clinical treatments, especially in cancer, hypertension and many other intractable diseases owing to their low toxicity and side-effects relative to western medicine. This article reviews literatures on development of TCM-targeted preparations which were published in the past 10 years. TDS including active-targeting, passive-targeting and physical-chemical-targeting preparations were introduced through domestic and overseas literatures to reveal the unique advantages of TCM-targeting preparations in drug delivery system. In this article, we have reviewed some kinds of TCM-targeting preparations and indicated that great attention should be paid to the research on the TCM-targeting preparations.

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, then mixing them together to prepare hydrogel through the heat-initiated free radical polymerization method. Differential scanning calorimetry and X-ray diffraction methods were used to verify whether dexamethasone was loaded into hydrogels. In vitro drug release behavior and in vivo pharmacokinetic study were also investigated in detail.Results: Dexamethasone was successfully loaded into hydrogel, and its loading capacity was improved (5 mg/g). Both the in vitro release study and the in vivo pharmacokinetic study showed the good colon-targeting character of the pH-sensitive P(LE-IA-MEG) hydrogel (T max ¼ 1.0 h, C max ¼ 2.16 mg/ml of dexamethasone; T max ¼ 3.9 h, C max ¼ 0.43 mg/ml of dexamethasone hydrogel). Discussion: Dexamethasone could be targeted to the colon site by P(LE-IA-MEG) hydrogel, thereby improving its therapeutic effect and reduce its side effects. Conclusion: P(LE-IA-MEG) hydrogel might have great potential application in colon-targeted drug delivery systems. KeywordsDexamethasone, drug-loading, in vitro drug release study, in vivo pharmacokinetic study, pH-sensitive History

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