Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel

Dong, Kai; Dong, Yalin; You, Cuiyu; Xu, Wei; Huang, Xiaoyan; Yan, Yan; Zhang, Lu; Wang, Ke; Xing, Jianfeng

doi:10.1016/j.colsurfb.2014.10.049

Cited by 11 publications

(13 citation statements)

References 51 publications

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“…CA converts carbon dioxide into carbonic acid, which eventually diffuses out of the membrane. 61 Carbonic acid decomposes into HCO 3 − and H + . The H + remains in the extracellular fluid and the HCO 3 − is taken up by the cell.…”

Section: Tumor Extracellular Ph Targetingmentioning

confidence: 99%

“…Over the last two decades, stimuli‐responsive smart nanomaterials have increasingly been considered to be attractive vehicles for the release of drugs and genes. Smart nanoparticles (NPs) are capable of reacting to cues in the form of changes in several environmental parameters including temperature, pH, light, electric and magnetic fields, ultrasound, mechanical stress, and biochemical stimuli . Therefore, owing to their nonlinear response to variations in these external signals, they have been called ‘smart or intelligent materials’ .…”

Section: Introductionmentioning

confidence: 99%

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pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Karimi

Eslami

Zangabad

et al. 2016

WIREs Nanomed Nanobiotechnol

198

105

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In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer’s. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers.

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Section: Tumor Extracellular Ph Targetingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Karimi

Eslami

Zangabad

et al. 2016

WIREs Nanomed Nanobiotechnol

198

105

View full text Add to dashboard Cite

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“…Acute oral toxicity, defined as the adverse effects that occur within a relatively short time after oral administration of a single dose or multiple doses of a substance in 24 h, can be estimated by using the maximum tolerated dose method. In this method, hydrogels are orally administered to animals, which are then continuously observed for 14 days for general conditions (hair, feces, energy, activity, behavior pattern and other clinical signs), after which blood and serum are collected for routine hematology and biochemistry analysis [ 76 ]. The hemolytic activity of hydrogels has been tested by determining the hemolysis caused by hydrogels in contact with human blood [ 77 ].…”

Section: Physical Chemical and Toxicological Properties Of Hydrogelsmentioning

confidence: 99%

Advanced biomedical hydrogels: molecular architecture and its impact on medical applications

Peters

Wechsler

Peppas

2021

Regenerative Biomaterials

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Hydrogels are crosslinked polymeric networks swollen in water, physiological aqueous solutions, or biological fluids. They are synthesized by a wide range of polymerization methods that allow for the introduction of linear and branched units with specific molecular characteristics. In addition, they can be tuned to exhibit desirable chemical characteristics including hydrophilicity or hydrophobicity. The synthesized hydrogels can be anionic, cationic, or amphiphilic, and can contain multifunctional crosslinks, junctions or tie points. Beyond these characteristics, hydrogels exhibit compatibility with biological systems, and can be synthesized to render systems that swell or collapse in response to external stimuli. This versatility and compatibility have led to better understanding of how the hydrogel’s molecular architecture will affect their physicochemical, mechanical, and biological properties. We present a critical summary of the main methods to synthesize hydrogels which define their architecture, and advanced structural characteristics for macromolecular/biological applications.

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“…Finally, 400 mL of the supernatant was obtained and concentrated to dry under nitrogen, and then dissolved in 80 mL of methanol for analysis by HPLC. 15 The linearity of the HSS concentration in rat blood was assessed by a calibration that obtained by plotting the peak area of each analyte versus HSS concentration. The concentrations were in the range of 1-300 mg mL À1 .…”

Section: Pharmacokinetic Studiesmentioning

confidence: 99%

In vitro and in vivo study of a colon-targeting pH-sensitive hydrocortisone sodium succinate hydrogel

et al. 2015

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Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel

Cited by 11 publications

References 51 publications

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Advanced biomedical hydrogels: molecular architecture and its impact on medical applications

In vitro and in vivo study of a colon-targeting pH-sensitive hydrocortisone sodium succinate hydrogel

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