Hydrogen peroxide-producing<i>Lactobacilli</i>in the vaginal flora of pregnant women with preterm labor with intact membranes

Kim, Y.H.; Kim, C.H.; Cho, M.K.; Na, J.H.; Song, Tae Bok; Oh, Jonghyun

doi:10.1016/j.ijgo.2006.01.013

Cited by 16 publications

(7 citation statements)

References 17 publications

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“…of group A managing to abolish the growth within 6 h. Lactobacilli are potent lactic acid producers. Other antimicrobial substances produced by lactobacilli include bacteriocins or metabolites, such as hydrogen peroxide (36–38). Whether production of bacteriocin, or of other factors, was the main source of lactobacillus‐mediated interference, remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus‐mediated interference of mutans streptococci in caries‐free vs. caries‐active subjects

Simark-Mattsson

Emilson

Håkansson

et al. 2007

European J Oral Sciences

112

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In order to assess whether naturally occurring oral lactobacilli have probiotic properties, lactobacilli were isolated from saliva and plaque from children and adolescents, with or without caries lesions. The interference capacities of these lactobacilli were investigated against a panel of 13 clinical isolates and reference strains of Streptococcus mutans and Streptococcus sobrinus, as well as against the subject's autologous mutans streptococci, using the agar-overlay technique. Lactobacillus-mediated inhibition differed significantly between the three subject groups (no caries, arrested caries, or active caries), demonstrating increased inhibition in subjects without present or previous caries experience compared to subjects with arrested caries or subjects presenting with frank lesions. Lactobacilli from subjects lacking S. mutans inhibited the growth of the test panel of mutans streptococci significantly better than lactobacilli from subjects who were colonized. Furthermore, subjects without caries experience harbored lactobacilli that more effectively repressed the growth of their autologous mutans streptococci. Twenty-three Lactobacillus spp. completely inhibited the growth of all mutans streptococci tested. Species with maximum interference capacity against mutans streptococci included Lactobacillus paracasei, Lactobacillus plantarum, and Lactobacillus rhamnosus. Naturally occurring oral lactobacilli significantly inhibited the growth of both test strains of mutans streptococci and the subject's autologous mutans streptococci in vitro, and this effect was more pronounced in caries-free subjects.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus‐mediated interference of mutans streptococci in caries‐free vs. caries‐active subjects

Simark-Mattsson

Emilson

Håkansson

et al. 2007

European J Oral Sciences

112

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“…The protective role ascribed to H 2 O 2 largely stems from epidemiological studies linking the presence in the vagina of H 2 O 2 -producing Lactobacillus spp. with a decreased risk for bacterial vaginosis (BV) [ 6 – 9 ], sexually transmitted infections [ 10 , 11 ], as well as adverse birth outcomes [ 12 ], compared to women harboring non-H 2 O 2 -producing vaginal Lactobacillus . Unfortunately, these epidemiological observations were interpreted into the now widely accepted statement that “in vivo, Lactobacillus spp.…”

Section: Main Textmentioning

confidence: 99%

“…In support of this proposal are issues with in vitro measurement of H 2 O 2 production, which can be affected by growth kinetics. As such, a third of non-H 2 O 2 -producing strains were shown to ‘convert’ to H 2 O 2 producers when the nutritional medium was reformulated [ 25 ] and in another study, 44% of non-H 2 O 2 -producing strains became producers when the time allowed for H 2 O 2 production was increased from 30 to 60 min [ 12 ], vividly demonstrating that the difference is one of rate rather than absolute ability. Consistent with these findings, and the hypothesis that H 2 O 2 is preferentially produced through NADH-dependent flavin mono-nucleotide reductase in lactic acid bacteria [ 13 , 28 , 29 ], an analysis of 125 L. iners genomes assembled from metagenomics datasets, showed that all genomes carry both genes found responsible for H 2 O 2 production in L. johnsonii [ 13 ] and other members of the L. acidophilus group (data not shown).…”

Section: Main Textmentioning

confidence: 99%

The implausible “in vivo” role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota

2018

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In the cervicovaginal environment, the production of hydrogen peroxide (H2O2) by vaginal Lactobacillus spp. is often mentioned as a critical factor to the in vivo vaginal microbiota antimicrobial properties. We present several lines of evidence that support the implausibility of H2O2 as an “in vivo” contributor to the cervicovaginal milieu antimicrobial properties. An alternative explanation is proposed, supported by previous reports ascribing protective and antimicrobial properties to other factors produced by Lactobacillus spp. capable of generating H2O2. Under this proposal, lactic acid rather than H2O2 plays an important role in the antimicrobial properties of protective vaginal Lactobacillus spp. We hope this commentary will help future research focus on more plausible mechanisms by which vaginal Lactobacillus spp. exert their antimicrobial and beneficial properties, and which have in vivo and translational relevance.

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“…Probiotics work by various mechanisms in the oral cavity, including the production of antibacterial agents against oral pathogens such as hydrogen peroxide organic acids and bacteriocins [23][24][25][26][27]. In another mechanism, probiotics compete with pathogenic agents for adhesion to the mucosa and teeth and prevent the attachment and invasion of pathogenic bacteria [28,29].…”

Section: Discussionmentioning

confidence: 99%

The role of probiotics in preventing dental caries

Shakib

Rouhi

Zolfaghary

2020

Plant Biotechnol Persa

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Tooth decay has occurred due to the numerous microorganisms in the mouth such as Streptococcus and Lactobacilli bacteria that can produce acid. Commercial antiplatelet agents are predominantly antibacterial compounds, but these compounds can disrupt oral bacterial flora and induce and enhance the growth of opportunistic pathogens, including Candida albicans. Nowadays, bacterial therapy is a replacement therapy for microorganisms. One of the methods of bacterial therapy is the use of probiotic bacteria. So far, many studies have been done on the effect of probiotic-containing food products on the microbial factors of tooth decay. Therefore, this study aimed to investigate the effect of probiotics on dental caries. The search queries were from ISI, PubMed, Scopus, Science Direct, magiran, SID databases. Key words were probiotic, dental caries, bacterial caries, tooth decay, laboratory and clinical studies. Finally, the selected articles were used for the review table. The results of the review of studies showed that probiotic strains are able to control bacterial agents that cause dental caries.

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Hydrogen peroxide-producingLactobacilliin the vaginal flora of pregnant women with preterm labor with intact membranes

Abstract: Distribution of hydrogen peroxide-producing Lactobacilli in vaginal flora as defense factors for infection may have an important role in the pathophysiology of preterm labor.

Cited by 16 publications

References 17 publications

Lactobacillus‐mediated interference of mutans streptococci in caries‐free vs. caries‐active subjects

Lactobacillus‐mediated interference of mutans streptococci in caries‐free vs. caries‐active subjects

The implausible “in vivo” role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota

The role of probiotics in preventing dental caries

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