Hydrogen peroxide-response nanoprobe for CD44-targeted circulating tumor cell detection and H2O2 analysis

Li, Chunting; Wang, Jiexuan; Lu, Xinmiao; Huang, Guocheng; Jin, Xin; Guan, Qinhua; Su, Yue; Pan, Ruijun; Li, Peiyong; Cai, Wei; Zhu, Xinyuan

doi:10.1016/j.biomaterials.2020.120071

Cited by 36 publications

(20 citation statements)

References 32 publications

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“…S37 (ESI †), the macroscopic metastatic nodules marked with red circles were clearly observed, which indicated successful modeling. CLSM images showed that DiD-labelled tumor cells with irregular morphology 25 were present in mice peripheral blood and green fluorescence of GluCC was only found in those irregular cells labelled with DiD. This result indicates that GluCC possesses the ability of specific and ultrasensitive CTC detection.…”

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confidence: 85%

A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells

Wang

Chen

et al. 2022

Chem. Commun.

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confidence: 85%

A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells

Wang

Chen

et al. 2022

Chem. Commun.

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“…Currently, the main principles of isolating CTCs are based on the cells’ physical properties, 10 immunochemical properties, 11 microfluidic technology, 12 and other factors. 13–15 However, current approaches inevitably also isolate untargeted cells due to the nonspecific adsorption. 16–20 Most methods are releasing all captured cells through external stimulation, 21–24 and the batch of cells collected for genetic analysis would also contain untargeted cells, which may lead to inaccurate results.…”

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confidence: 99%

A light-induced hydrogel responsive platform to capture and selectively isolate single circulating tumor cells

et al. 2022

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“…Dendritic polymers, including dendrons, dendrimers, hyperbranched polymers, dendrigraft polymers and other dendritic hybrid polymers (Cook & Perrier, 2020), have emerged to deliver imaging probes or function as imaging reporters (El‐Betany et al, 2020; Jin et al, 2018; Y. Zeng, Li, et al, 2020), as well as capture cancer markers, such as circulating tumor cells (CTCs), cell‐free tumor DNA (ctDNA), and tumor derived exosomes (Bu et al, 2020; J. Dong et al, 2020; Poellmann et al, 2020). The intrinsic physiochemical properties endow the dendritic polymers with unique advantages in cancer diagnosis, and the use of dendritic polymer‐based nanomedicines is of great help in effectively diagnosing early stage tumors and tracking the information on tumor characterization, invasiveness, metastasis, and prognosis (C. Li, Wang, et al, 2020; Tan et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

173

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

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Hydrogen peroxide-response nanoprobe for CD44-targeted circulating tumor cell detection and H2O2 analysis

Cited by 36 publications

References 32 publications

A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells

A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells

A light-induced hydrogel responsive platform to capture and selectively isolate single circulating tumor cells

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

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