Hydrogen peroxide tooth-whitening (bleaching): Review of safety in relation to possible carcinogenesis

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

“…[126][127][128][129][130][131][132][133][134][135][136][137] As such, hydrogen peroxide may be directly involved in the earliest tumor initiating events. 126,127,137,138 In accordance with this notion, addition of catalase to the extracellular tissue culture media is indeed sufficient to prevent or dramatically delay the onset of cell transformation and genomic instability, when normal cells are presented with an oncogenic stimulus. 138 Thus, we propose that carcinogenesis may be a 3-step process, related to hydrogen peroxide production, as outlined in Figure 5A and B.…”

“…125,126 Thus, hydrogen peroxide may also induce DNA damage in normal epithelial cells. 126,127 can be distinguished from normal controls, based on the detection of hydrogen peroxide in their exhaled breath.…”

“…125,126 Thus, hydrogen peroxide may also induce DNA damage in normal epithelial cells. 126,127 can be distinguished from normal controls, based on the detection of hydrogen peroxide in their exhaled breath. [110][111][112] Consistent with the idea that hydrogen peroxide may also originate from the tumor stroma, patients with interstitial pulmonary fibrosis show increased levels of hydrogen peroxide in their exhaled breath.…”

Hydrogen peroxide tooth-whitening (bleaching) products: Review of adverse effects and safety issues

“…An extensive review of these has been undertaken by Naik et al (2006). 68 The following provides a brief overview of this area.…”

Influência do peróxido de carbamida sobre a gengiva marginal – estudo em camundongos

“…O peróxido de hidrogênio dissocia-se em água e oxigênio, e a ureia, por sua vez, decompõe-se em dióxido de carbono e amônia. Uma elevada concentração do peróxido de hidrogênio (30% a 35%) é conhecida por ser cáustica à mucosa oral, podendo ocasionar queimadura nos tecidos moles 11 . Estudos clínicos utilizando peróxido de carbamida com moldeiras em clareamento caseiro indicaram que 25% a 40% dos pacientes relataram irritação gengival durante o tratamento 12,13 .…”